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First received: September 11, 2025

Clinical Trial: Light-Activated Antimicrobial Therapy to Prevent Surgical Site Infections - Canada

Study Status: COMPLETED

Recruit Status: COMPLETED

Condition: Surgical Site Infections
Infections
Surgical Wound Infections
Anti-Infective Agents

Study Type: INTERVENTIONAL


Official Title: A Group-Randomized, Standard-of-Care-Controlled, Crossover Trial Evaluating Nasal Antimicrobial Photodisinfection for the Prevention of Surgical Site Infections

Brief Summary: This is a Phase 4 multi-center, group-randomized, crossover trial to compare nasal antimicrobial photodisinfection therapy (aPDT) with standard of care for prevention of surgical site infections in patients undergoing major elective, urgent, or emergent surgeries in a hospital setting. The main outcomes are to:1. compare the efficacy, and2. estimate the safety of applying nasal (aPDT) before surgery in reducing the incidence of SSIs within the initial 30 days after surgery compared to standard of care…

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