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Chronic XBP1s-mediated activation of the unfolded protein response impairs CD8 + T cell anti-tumor immunity

Abstract: CD8 + T cells play a crucial role in anti-tumor immunity; however, their functionality is compromised by exhaustion driven by chronic antigen exposure, poor tumor…

Date: 2026-10-02

Heterogeneous profiles of eHealth literacy in older adults with type 2 diabetes: a latent profile analysis and associated factors

Abstract: Digital diabetes services are expanding rapidly in China, and older patients’ uptake of them depends on their eHealth literacy. This construct is usually reported as a…

Date: 2026-10-02

Healthy sleep pattern is associated with reduced risk of incident thyroid disease: a prospective cohort study from the UK Biobank

Abstract: The longitudinal association between sleep behaviors and the incidence of various thyroid diseases remains unclear. This study aimed to prospectively investigate the…

Date: 2026-10-02

Accuracy, potential harm, weight stigma, and commercial influence in short-form social media content on incretin-based therapies for obesity

Abstract: Short-form video platforms such as TikTok and YouTube Shorts are major sources of health information, yet little is known about the reliability of what they carry on…

Date: 2026-10-02

Burden of dermatology outpatient and inpatient services in China, 2011–2023

Abstract: This study aimed to describe the temporal trends, regional distribution of dermatology services, and the hospitalization burden of common skin diseases in China…

Date: 2026-10-02

Vacuole histomorphology characteristics and their same immunophenotype with the gut wall: A histological study using human fetuses

Abstract: Intestinal atresia (IA) has been associated with abnormal embryonic intestinal recanalization, a developmental process in which transient vacuoles form and merge with…

Date: 2026-10-02

White blood cell and neutrophil trends in likely early-onset neonatal sepsis: a sex-stratified analysis before and after antibiotic therapy

Abstract: Early-onset neonatal sepsis (EONS) requires rapid diagnosis, yet the interpretation of white blood cell (WBC) and absolute neutrophil count (ANC) is complicated by…

Date: 2026-10-02

Development and validation of a nomogram for stratifying severe Mycoplasma pneumoniae pneumonia risk in children early

Abstract: This study aimed to develop and validate a clinically applicable diagnostic predictive model to facilitate early identification of severe Mycoplasma pneumoniae pneumonia…

Date: 2026-10-02

Multiparametric MRI-based habitat and peritumoral radiomics integrating semi-automated segmentation for preoperative prediction of high-grade prostate cancer: a dual-center study

Abstract: This study aimed to develop and validate an interpretable machine learning framework that combines semi-automated segmentation, intratumoral habitats derived from…

Date: 2026-10-02

An explainable and leakage-aware machine learning model for early risk stratification of radioiodine-refractory differentiated thyroid cancer: development and single-center geographic external validation

Abstract: Radioiodine-refractory differentiated thyroid cancer (RAIR-DTC) poses a major therapeutic challenge, with loss of radioiodine avidity, limited treatment options, and…

Date: 2026-10-02