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Course: Treatment Options for Locally Advanced Cutaneous Squamous Cell Carcinoma

CME Credits: 0.25

Released: 2026-09-11

Locally advanced cutaneous squamous cell carcinoma (cSCC) with deep invasion but reassuring pathology can still pose some of the most challenging postoperative treatment decisions in cSCC care. Despite evolving risk-stratification frameworks and new data supporting postoperative immunotherapy in extremely high-risk disease, current tools remain imperfect, and clinicians are often left weighing adjuvant radiation, immunotherapy, or active surveillance without a clear predictor of recurrence. This online, on-demand CME/CE activity—part of the six-part series Mock Tumor Board: Advancing Multidisciplinary Decision-Making in Cutaneous Squamous Cell Carcinoma—presents an interactive mock tumor board case of a patient with locally advanced cSCC involving deep invasion to the parotid gland. Throughout the discussion, expert faculty examine multidisciplinary decision-making around surgery, adjuvant radiation, and postoperative immunotherapy along with the latest efficacy and safety data. They also discuss optimal coordination of surgical and reconstructive planning with radiation oncology, the evolving role of postoperative immunotherapy in extremely high-risk cSCC, and the complexities of managing recurrence in patients who lack traditional high-risk pathologic features. The content for this enduring activity was recorded on July 27, 2026.


Upon completion of this activity, participants should be better able to:


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