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Course: Management of Locally Advanced and Unresectable Cutaneous Squamous Cell Carcinoma

CME Credits: 0.25

Released: 2026-09-11

Locally advanced and unresectable cutaneous squamous cell carcinoma (cSCC) with perineural spread toward the skull base presents some of the most challenging multidisciplinary treatment decisions in cSCC care. Despite mounting evidence that upfront immunotherapy can benefit these patients, many are still steered toward surgery or radiation before oncology and other specialists are consulted, and evaluations conducted in isolation can obscure a true multidisciplinary consensus. This online, on-demand CME/CE activity—part of the six-part series Mock Tumor Board: Advancing Multidisciplinary Decision-Making in Cutaneous Squamous Cell Carcinoma—presents an interactive mock tumor board case of a patient with recurrent, locally advanced cSCC and perineural spread to the skull base, examining the risks and benefits of upfront immunotherapy versus surgery and radiation, as well as the latest efficacy and safety data. Expert faculty will also discuss risk-benefit considerations for treating disease near critical structures such as the brainstem and strategies for ensuring truly collaborative, multidisciplinary evaluation before a treatment path is chosen. The content for this enduring activity was recorded on July 27, 2026.


Upon completion of this activity, participants should be better able to:


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