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Research Article: Malnutrition risk factors and a pre-post evaluation of a multicomponent management program in older inpatients with chronic heart failure: a single-centre retrospective study

Date Published: 2026-09-30

Abstract:
To investigate nutritional impairment-related outcomes admission among hospitalized older patients with chronic heart failure (CHF) and to conduct a pre-post evaluation of the clinical effect of a unified multicomponent management program delivered to all enrolled patients during their inpatient stay. A single-centre retrospective observational study was split into two independent analytical parts. Part 1: Retrospective risk factor and model construction analysis: We screened 200 complete medical records of elderly CHF inpatients admitted from March 2023 to March 2024, stratified participants into nutritionally impaired ( n =?71) and non-impaired ( n =?129) groups based on combined admission GNRI + NRS2002 assessment using a pre-defined “and” algorithm: impaired if GNRI ?98 and NRS2002???3; non-impaired if GNRI >98 and NRS2002?<?3, then performed univariate, multicollinearity and multivariate logistic regression analyses to screen nutritional risk-related variables and construct an internally validated nomogram prediction model, only using cross-sectional admission data without repeated follow-up assessment. Uncontrolled inpatient before-after observational sub-study: All 200 enrolled patients received a unified full-hospital multicomponent management program, which was uniformly implemented from the first day of each patient’s admission throughout their entire hospital stay. Nutritional risk status, NYHA classification, Hb, CRP, and SAS scores were measured at two fixed time points: baseline (admission day, before intervention initiation) and discharge day (post full-course intervention). No parallel control group was set, no external follow-up after discharge was conducted, and all 200 patients had complete paired admission-discharge data with zero loss to follow-up; routine standard heart failure drug treatment remained consistent for all subjects during hospitalization without additional concurrent therapeutic adjustments. Collinearity diagnostics and logistic regression were applied for the risk factor section; paired t -tests and chi-square tests were adopted for within-cohort before-after comparisons. Missing clinical data were excluded prior to analysis; only fully documented cases were retained. Univariate testing revealed significant intergroup differences in smoking history, NYHA cardiac function classification, hemoglobin (Hb), C-reactive protein (CRP), and SAS scores (all p <?0.05), with no severe multicollinearity detected (variance inflation factor ? 10, tolerance ? 0.1). Multivariate logistic regression identified smoking history (OR?=?2.437, p =?0.003), NYHA classification (OR?=?2.632, p =?0.002), Hb (OR?=?0.921, p <?0.001), CRP (OR?=?2.894, p <?0.001), and SAS score (OR?=?1.086, p <?0.001) as factors independently associated with. The nomogram prediction model built on these five indicators yielded an AUC of 0.869 (95% CI: 0.814–0.923) on internal ROC validation, with a non-significant Hosmer-Lemeshow goodness-of-fit p -value of 0.266, demonstrating satisfactory discriminative and calibration performance. The combined “and” algorithm identified 71 impaired patients, while GNRI alone flagged 89 patients and NRS2002 alone flagged 78 patients; the overlap between the two tools is illustrated in a Venn diagram. After standardized implementation of the multicomponent management program for all patients, the proportion of patients with NYHA class I–II increased, while the proportion with NYHA class III–IV and the admission-determined nutritional impairment rate declined significantly (all p <?0.05). Marked improvements in Hb, CRP, and SAS scores were also observed post-intervention relative to admission baseline (all p <?0.05). Hospitalized older CHF patients bear a prominent admission nutritional impairment burden. Smoking history, NYHA classification, Hb, CRP, and SAS score are independently associated with admission nutritional impairment-related variables, and the established nomogram can assist clinical high-risk population screening. The uncontrolled inpatient before-after comparison demonstrated significant improvements in cardiac function, nutritional risk status, inflammatory markers, and anxiety after the multicomponent management program; due to the absence of a control group and potential confounding inpatient factors, causal effects of the intervention cannot be confirmed; only observational within-cohort changes are described. This study provides real-world retrospective evidence including a nutritional risk prediction model and preliminary observational intervention outcomes, with major limitations consisting of a single-centre design and an uncontrolled pre-post comparison lacking parallel controls.

Introduction:
Chronic heart failure (CHF) is an end-stage cardiovascular syndrome characterized by impaired cardiac pump function, and population aging has drastically elevated its prevalence among ( 33–35 ) adults over 65?years old worldwide, with reported rates ranging from 10 to 12% ( 1 , 2 ). Progressive cardiac dysfunction triggers circulatory stasis, persistent inflammation and neuroendocrine activation, which collectively increase the risk of nutritional impairment-a frequently overlooked but detrimental complication in…

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