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Recognition of the novel items for prediction of bone metastasis in colorectal cancer

Abstract: To explore whether uric acid (UR), neutrophil/lymphocyte ratio (NLR) and uric acid/albumin ratio (UAR) can predict bone metastasis in colorectal cancer (CRC). A…

Date: 2025-10-21

The impact of ?-blockers on outcomes of immune checkpoint inhibitors therapy in advanced lung cancer: a multicenter real-world study

Abstract: Immune checkpoint inhibitors (ICIs) have improved outcomes in advanced lung cancer. ?-adrenergic signaling may promote tumor initiation and progression, and ?-blockers…

Date: 2025-10-21

Phenotypic aging mediates the association between neutrophil percentage-to-albumin ratio and muscular dystrophies: a population-based study

Abstract: Current research on Muscular Dystrophies (MD) suggests that its occurrence is closely related to several mechanisms, including gene mutations, dystrophin deficiency, and…

Date: 2025-10-21

Unveiling hypoxic regulatory networks by bioinformatics: mechanisms of hypoxia-related hub genes driving rituximab resistance and poor prognosis in DLBCL

Abstract: Diffuse large B-cell lymphoma (DLBCL), an aggressive subtype of non-Hodgkin lymphoma, exhibits heterogeneous clinical outcomes. While rituximab, a CD20 inhibitor,…

Date: 2025-10-20

Platelet count and sleep quality in immune thrombocytopenia: correlation with 5-hydroxytryptamine and therapeutic implications of platelet-5-HT-melatonin axis dysregulation

Abstract: Immune thrombocytopenia (ITP) disrupts platelet homeostasis via autoimmune mechanisms, yet its systemic effects beyond bleeding risk remain poorly characterized. Sleep…

Date: 2025-10-20

The power of GM-CSF: immune regulation in the defense against Phialophora verrucosa infection

Abstract: Phialophora verrucosa , a dematiaceous fungus, causes serious infections such as phaeohyphomycosis. These infections can severely impair patient quality of life and may…

Date: 2025-10-20

Acceptance and impact of Nirsevimab and the RSVpreF vaccine following implementation in Austria

Abstract: Since summer 2024, passive immunization with nirsevimab (Beyfortus ® ) has been recommended for all infants in Austria to prevent severe respiratory syncytial virus…

Date: 2025-10-20

Regional and age-specific global trends associated with infectious diarrhea in children under 14?years old caused by pathogenic microorganisms in 2021

Abstract: This study aimed to systematically analyze the morbidity and mortality of infectious diarrhea in children under 14?years old caused by pathogenic microorganisms globally…

Date: 2025-10-20

Hydromorphone ameliorates postoperative pain and depressive disorder in women receiving cesarean section under spinal anesthesia

Abstract: Pain and depressive mood disorders during cesarean sections negatively impact both mothers and infants. Studies have shown that hydromorphone has positive effects on…

Date: 2025-10-20

Association between iron deficiency anemia and risk of venous thromboembolism: a multi-institutional retrospective study

Abstract: Iron deficiency anemia (IDA) represents the most prevalent nutritional deficiency globally, affecting approximately one-third of the world’s population. Despite its…

Date: 2025-10-20