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Mean systolic blood pressure upon admission and clinical outcomes after endovascular treatment in patients with large vessel occlusion beyond 24 hours

Abstract: Recently, several clinical studies have shown that higher systolic blood pressure (SBP) upon admission is associated with poor clinical outcomes in patients with…

Date: 2026-04-21

Clinical and biological factors associated with the presence of peripheral neuropathy in patients with rheumatoid arthritis

Abstract: Immune dysfunction in rheumatoid arthritis (RA) is a contributing factor to the development of peripheral neuropathy (PN). The objective of our study was to investigate…

Date: 2026-04-21

High-risk and low-risk human papillomavirus detection in self-collected samples compared to clinician-collected samples in a Polish population

Abstract: Persistent infections with human papillomavirus (HPV) cause approximately 95% of cervical cancers. The introduction of cytology screening has, however, significantly…

Date: 2026-04-21

Mast cell release of TNF-? indirectly contributes to recalling B cells in the colorectal cancer milieu through the CCL20/CCR6 axis

Abstract: In colorectal cancer (CRC), mast cells (MCs) modulate tumor and immune cell interactions, influencing patient prognosis, though their role remains not fully elucidated.…

Date: 2026-04-21

Assessment of real-world surveillance strategies for patients undergoing systemic therapy for brain metastases

Abstract: Radiotherapy has long been first-line treatment for brain metastases. However, CNS penetrating systemic therapies are increasingly used as first-line alternatives. There…

Date: 2026-04-20

Real-world incidence of G3-G4 adverse events in patients with advanced renal cell carcinoma receiving immune-combinations (ARON-1)

Abstract: Immune-based combination therapies have become the standard first-line treatment for metastatic renal cell carcinoma (mRCC) and have positively impacted survival…

Date: 2026-04-20

Endocrinologist-led glucose management in the emergency ICU: a retrospective before-after study

Abstract: To evaluate the effectiveness and safety of an endocrinologist-led glucose management (ELGM) model integrating real-time continuous glucose monitoring (RT-CGM) and…

Date: 2026-04-20

Case report and literature review: isolated ACTH deficiency induced by combined nivolumab and trastuzumab therapy in gastric adenocarcinoma

Abstract: Isolated adrenocorticotropic hormone (ACTH) deficiency (IAD) is an uncommon endocrine disorder characterised by the selective reduction or absence of pituitary ACTH…

Date: 2026-04-20

Biomarker-based clustering identifies distinct pulmonary function trajectories in early systemic sclerosis

Abstract: Systemic sclerosis (SSc) is a heterogeneous autoimmune disease in which interstitial lung disease (ILD) is a major determinant of mortality. Given that certain…

Date: 2026-04-20

Epigenetic downregulation of MAPKAPK2 exacerbates oxidative stress-induced damage in vitiligo melanocyte cell line model

Abstract: Vitiligo is an acquired depigmentation disorder caused by melanocyte dysfunction or loss. Oxidative stress is widely considered a key driver to its pathogenesis.…

Date: 2026-04-20