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Novel RNA-methylase HNRNPC promotes gastric cancer tumorigenesis by triggering the lactate-induced ferroptosis resistance

Abstract: Emerging evidence gradually indicates that lactate and iron-induced cell death plays important role in gastric cancer (GC) progression. Here, this study focused on the…

Date: 2025-09-04

Loss of ATG5 impairs CD4+ T cell activation and promotes anti-tumor responses

Abstract: Macroautophagy (hereafter called autophagy) is an ancient catabolic process that delivers bulky cargo to lysosomal degradation. The autophagic pathway is regulated by…

Date: 2025-09-04

Phase-specific mortality risk of serum lactate thresholds in very low birth weight infants with late-onset sepsis: a retrospective cohort study

Abstract: Late-onset sepsis (LOS) in very low birth weight (VLBW) infants confers substantial mortality risk. While lactate monitoring is standard, validated prognostic thresholds…

Date: 2025-09-04

Machine learning-based nomogram predicts heart failure risk in elderly relapsed/refractory multiple myeloma patients receiving carfilzomib-based therapy

Abstract: To develop and validate a machine learning-based nomogram for predicting heart failure (HF) in elderly patients with relapsed/refractory multiple myeloma (RRMM)…

Date: 2025-09-03

Patient involvement in treatment decisions is associated with increased therapy satisfaction in Hidradenitis suppurativa

Abstract: Hidradenitis suppurativa (HS) is a painful and disfiguring chronic inflammatory skin disease. Despite many efforts over the past decade to improve the care of patients…

Date: 2025-09-03

Endotheliopathy syndromes, TA-TMA, and SOS, are risk factors for morbidity and mortality in critically ill pediatric hematopoietic cell transplant recipients

Abstract: Pediatric hematopoietic cell transplant (HCT) recipients who require intensive care unit (PICU) admission historically have high mortality rates. The HCT landscape is…

Date: 2025-09-03

Central memory-enriched V?9V?2 ?? T cells via TGF-? expansion demonstrate enhanced in vivo efficacy against metastatic osteosarcoma

Abstract: The application of cellular immunotherapies (CI) for osteosarcoma (OS) has mainly focused on autologous products of ?? T cells and, to date, has shown little clinical…

Date: 2025-09-03

Conditioning regimens in pediatric myeloid malignancies undergoing allogeneic HSCT: a comparative single-center study

Abstract: Optimal conditioning regimen for pediatric myeloid malignancies is still subject for debate. This single-center retrospective study compares the efficacy and toxicity…

Date: 2025-09-03

The value of combined examination of serum serum heparin binding protein, tumor necrosis factor alpha, interleukin-6, platelet count, and c-reactive protein in evaluating the condition and prognosis of children with adenovirus pneumonia

Abstract: Adenovirus pneumonia presents a significant challenge in pediatric care, with severe children leading to significant morbidity. The study evaluated the combined…

Date: 2025-09-03

Hyaluronan in the pathogenesis of lung fibrosis associated to autoimmune pulmonary alveolar proteinosis (aPAP)

Abstract: Pulmonary fibrosis is a rare event occurring in patients with autoimmune Pulmonary Alveolar Proteinosis (aPAP). The accumulation of intra-alveolar material may promote…

Date: 2025-09-03