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Ghrelin’s potential as a therapeutic target for chronic inflammatory diseases: evidence from human endometrial stromal cells

Abstract: Ghrelin, a peptide composed of 28 amino acids, is recognized for its role in regulating appetite and energy balance. Recently, it has also been identified as an…

Date: 2025-09-01

Evaluating the toxicity profile of combination immune checkpoint inhibitors: a disproportionality analysis of real-world adverse events from the FDA Adverse Event Reporting System for tremelimumab, durvalumab, ipilimumab, and nivolumab

Abstract: As one of the therapeutic modalities for treating tumors, immune checkpoint inhibitors (ICIs) have gained widespread application in clinical practice, including…

Date: 2025-09-01

Cognitive effort devaluation and the salience network: a computational model of amotivation in depression

Abstract: Amotivation in depression is linked to impaired reinforcement learning and effort expenditure via the dopaminergic reward pathway. To understand its computational and…

Date: 2025-09-01

Mental health consequences for adolescents during the Russian invasion of Ukraine: protocol for the Ukraine Adolescent Mental Health Study

Abstract: In February 2022, Russia launched a full scale-invasion of Ukraine, which is the largest European ground offensive since the Second World War. However, the…

Date: 2025-09-01

Multi-informant measurement of social anxiety symptoms in youth with social anxiety with and without autism

Abstract: Discrepancies between caregiver and youth report of social anxiety symptoms persist, yet measuring social anxiety symptoms, particularly among autistic youths, is…

Date: 2025-09-01

Reversed sex disparities in heart failure mortality in Spain, 2000–2023: a population-based analysis of older adults

Abstract: Heart failure (HF) is a growing public health concern in Spain, ranking as the third leading cause of cardiovascular mortality and contributing substantially to…

Date: 2025-09-01

Whole mitochondrial genome sequencing in individuals with Leber hereditary optic neuropathy negative for the common pathogenic mitochondrial DNA variants

Abstract: This study aimed to explore the role of additional mitochondrial DNA (mtDNA) variants in the development of Leber hereditary optic neuropathy (LHON) by screening the…

Date: 2025-09-01

Transformation of the private healthcare sector in the Republic of Kazakhstan following healthcare reforms

Abstract: In Kazakhstan, transformation of the private healthcare sector as the country transitioned from lower-middle-income to upper-middle-income status has rarely been a…

Date: 2025-09-01

Single-cell RNA-seq reveals a repair pattern in cystic lesions in steroid induced osteonecrosis of the femoral head

Abstract: Studies have indicated that cystic lesions play a crucial role in the repair processes of steroid-induced osteonecrosis of the femoral head and its subsequent collapse.…

Date: 2025-09-01

Comparative clinical outcomes of dual cannulated screw-cable system vs. Kirschner wire-cable fixation in type C patellar fractures

Abstract: To compare the clinical efficacy and safety of the dual cannulated screw-cable (DCSC) system with those of conventional Kirschner wire-cable (KWC) fixation in the…

Date: 2025-09-01