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A vessel-guided multi-task deep learning framework with visual interpretability for simultaneous retinal vessel segmentation and multi-disease classification from fundus images

Abstract: Retinal diseases represent a leading cause of visual impairment and blindness worldwide, with early and accurate diagnosis being crucial for preventing irreversible…

Date: 2026-04-17

Femtosecond laser assisted phacoemulsification plus IOL implant: toric IOL vs. astigmatic keratotomy

Abstract: To compare the clinical outcomes of femtosecond laser-assisted cataract surgery (FSLACS) with astigmatic keratotomy (AK) versus toric intraocular lens (IOL t )…

Date: 2026-04-17

Peroral endoscopic myotomy provides effective and sustained relief for achalasia in Allgrove syndrome: a long-term comparative cohort study

Abstract: Allgrove syndrome is a rare autosomal recessive disorder characterized by the triad of alacrima, adrenal insufficiency, and achalasia. Although corticosteroid…

Date: 2026-04-17

Multiple inflammatory cytokines correlate with the vestibular and oculomotor dysfunction in Fabry disease: a prospective, longitudinal study

Abstract: Vestibular and oculomotor abnormalities have been widely identified in Fabry disease (FD), with inflammation potentially playing an important role. We aim to investigate…

Date: 2026-04-17

Cost-effectiveness analysis of a telemedicine network for acute neurological care in northeast Germany (ANNOTeM)

Abstract: Expert neurological care in rural areas remains a major challenge and contributes to disparities in outcomes after acute neurological emergencies. To address this gap,…

Date: 2026-04-17

LINC02470 impairs natural killer cell cytotoxicity by epigenetically targeting the natural cytotoxicity triggering receptor 1

Abstract: Natural killer cells (NK cells) play a critical role in the surveillance of tumor immunity. However, NK cell-based immunotherapy, including autologous and allogeneic NK…

Date: 2026-04-16

The profile of clinical and laboratory features of Chinese VEXAS syndrome patients with hematological abnormalities: a single-center case series

Abstract: VEXAS syndrome is a recently characterized hemato-inflammatory disorder caused by somatic mutations in the X-linked UBA1 gene in hematopoietic cells, which remains…

Date: 2026-04-16

Macrophage and IL-6 signaling modulate multiple myeloma progression and response to metformin and CAR-T cell therapy

Abstract: The tumor microenvironment (TME) plays a crucial role in tumor progression and therapeutic response. Monocytes and macrophages, depending on their phenotype, can either…

Date: 2026-04-16

Single-cell landscape of melanoma reveals ETV5-driven C3 ID4 + tumor subpopulation with extracellular vesicle-associated immunosuppressive and pro-metastatic potential

Abstract: Malignant melanoma is characterized by marked intratumoral heterogeneity and an immunosuppressive tumor microenvironment (TME), and resistance to immunotherapy remains…

Date: 2026-04-16

Economic cost of Hansen’s disease: an overview of social security expenditures

Abstract: Brazil is the second highest worldwide regarding new cases of Hansen’s disease (HD), with over 20,000 diagnoses annually. Late detection often results in severe…

Date: 2026-04-16