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TRP-related gene signatures predict survival and the immune microenvironment in rectal cancer: a comprehensive bioinformatics study

Abstract: The pathogenesis of rectal cancer (RC) involves a variety of biological mechanisms; however, the prognostic significance of temperature-sensitive receptor (TRP) channels…

Date: 2025-09-02

Developing models for the diagnosing of ulcerative colitis and prognosis of anti-TNF-? non-response based on neutrophil extracellular trap-associated genes

Abstract: Neutrophil extracellular traps (NET) play a pivotal role in the pathogenesis of ulcerative colitis (UC) and may contribute to the impaired response to anti-tumor…

Date: 2025-09-02

Malignant epithelia cells-derived spermine induces APOE+ macrophages to suppress tumor immunity in adenocarcinoma of the esophagogastric junction

Abstract: Adenocarcinoma of the esophagogastric junction (AEG) is increasingly recognized as a distinct gastrointestinal tumor type with a poor prognosis. However, the mechanisms…

Date: 2025-09-02

Adverse events of ursodeoxycholic acid: a real-world pharmacovigilance study using FAERS (2004–2023)

Abstract: Ursodeoxycholic acid (UDCA) has been widely used in the treatment of hepatobiliary disorders and its clinical application is more and more extensive. However, to our…

Date: 2025-09-02

Association between inflammatory markers (SII and SIRI) and anxiety levels in Parkinson’s disease

Abstract: Parkinson’s disease (PD) is a progressive neurodegenerative disorder frequently associated with anxiety, which can significantly impair patients’ quality of life.…

Date: 2025-09-02

Research paper efficacy and safety of telitacicept combined with standard therapy for lupus nephritis: a single-center real-world study

Abstract: Lupus nephritis (LN) is a severe complication of systemic lupus erythematosus with suboptimal response to standard therapy. This study evaluated the efficacy and safety…

Date: 2025-09-02

Safety and clinical outcomes of orelabrutinib, lenalidomide plus sintilimab for relapsed/refractory diffuse large B-cell lymphoma

Abstract: This study evaluated the safety and clinical outcomes of orelabrutinib, lenalidomide plus sintilimab in relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL).…

Date: 2025-09-01

The relationship between early adulthood obesity and sarcopenic obesity among middle-aged and older adults in the United States

Abstract: This study aimed to explore the relationship between early adulthood obesity and sarcopenic obesity (SO) among middle-aged and older adults in the United States. This…

Date: 2025-09-01

Impact of a high dietary fiber cereal meal intervention on the progression of liver fibrosis in T2DM with MASLD

Abstract: This study aimed to investigate the ameliorative effect of dietary fiber on hepatic fibrosis in T2DM combined with MASLD and to seek the appropriate dose of DF for this…

Date: 2025-09-01

Identifying aging-related biomarkers in adipose tissue using integrative bioinformatics and machine-learning approaches: discovery of ELN, MXD1, and FGF21 as key genes

Abstract: Adipose tissue plays a critical role in aging and age-related diseases. However, the specific molecular and cellular alterations associated with aging in adipose tissue…

Date: 2025-09-01