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Integrating clinical and multiomics evidence based on disease module theory: deciphering the comorbidity network of psoriasis vulgaris via the Ising model for mechanistic insights

Abstract: Psoriasis vulgaris (PV), a chronic immune-mediated inflammatory dermatosis, is associated with a significant burden of systemic comorbidities. Traditional comorbidity…

Date: 2026-04-14

Experience in the management of real-world patients with chronic prurigo nodularis in a dermatology setting: results from the ECOSPIN Spanish survey-based study

Abstract: Chronic prurigo nodularis (CPN) is a chronic, inflammatory, highly pruritic skin disease with a significant burden, but the epidemiological data available are still very…

Date: 2026-04-14

Photobleaching-based autofluorescence mapping reveals distinct patterns in sporadic basal cell carcinoma, nevoid basal cell carcinoma syndrome-associated basal cell carcinoma and squamous cell carcinoma

Abstract: Autofluorescence (AF) imaging is a promising non-invasive tool for skin cancer diagnostics. However, AF intensity alone often fails to reliably delineate tumor…

Date: 2026-04-14

French public care in ophthalmology: a nationwide survey

Abstract: To describe the medical resources in ophthalmology departments of French public hospitals and to suggest what training needs could be relevant for the future. An online…

Date: 2026-04-14

Cognitive profile and inflammatory markers in children and adolescents with specific learning disorder: a cross-sectional study

Abstract: Specific learning disorder (SLD) is frequently characterized by weaknesses in working memory and processing speed; however, its biological correlates remain unclear. In…

Date: 2026-04-13

Efficacy, toxicity, and prognostic factors of rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone in elderly patients with diffuse large B-cell lymphoma: a single-center retrospective cohort study

Abstract: Optimizing treatment for elderly patients with diffuse large B-cell lymphoma (DLBCL) remains clinically challenging because curative intent must be balanced against…

Date: 2026-04-13

Comparison of time-segmented goal-directed teaching vs. traditional teaching for PICC among specialist nurse training: a randomized controlled trial

Abstract: This randomized controlled trial compared the efficacy of Time-Segmented Goal-Directed Teaching (TSGDT) vs. Traditional Teaching (TT) in enhancing Peripherally Inserted…

Date: 2026-04-13

Differential association of the 5-factor modified frailty index with postoperative pulmonary complications: specific prediction of infection risk after pulmonary lobectomy

Abstract: Frailty is recognized as an important predictor of postoperative outcomes, yet evidence on the differential association between the 5-factor modified frailty index…

Date: 2026-04-13

Association of the glucose metabolism continuum (fasting plasma glucose/HbA1c) with tear-film stability and secretion: ocular surface evidence across non-diabetes, prediabetes, and diabetes

Abstract: Whether gradations in glycemia across non-diabetes, prediabetes, and diabetes relate to tear?film homeostasis and dry eye disease (DED) remains uncertain, and…

Date: 2026-04-13

Unveiling the non-linear synergistic effects of smoking and aging on cataract-AMD comorbidity: an explainable artificial intelligence approach

Abstract: The comorbidity of cataract and age-related macular degeneration (AMD) poses a significant public health burden. Traditional linear statistical models often fail to…

Date: 2026-04-13