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Burden of ageing spectrum of diseases in China, 1990–2021: a systematic analysis of global burden of disease study 2021

Abstract: Population aging represents a pressing challenge for China, given its vast population and the growing proportion of adults aged 65?years and older. The study aimed to…

Date: 2025-07-29

ROR?-activated mitophagy attenuating hypoxic-ischemic encephalopathy via suppression of microglial cGAS-STING axis

Abstract: Hypoxic-ischemic encephalopathy (HIE) involves neuroinflammation driven by microglial activation, yet regulatory mechanisms remain poorly defined. This study…

Date: 2025-07-29

Development and validation of a CD4+/CD8+ ratio-based nomogram to predict plastic bronchitis in pediatric Mycoplasma pneumoniae pneumonia

Abstract: Plastic bronchitis (PB) is a rare but severe complication of Mycoplasma pneumoniae pneumonia (MPP) in children. Early identification of PB is critical for timely…

Date: 2025-07-29

Risk factors associated with renal injury in patients initially diagnosed with IgA vasculitis

Abstract: To explore the risk factors associated with renal injury in patients diagnosed with IgA vasculitis at initial presentation. A retrospective analysis was conducted on the…

Date: 2025-07-29

Nutritional and immune-inflammatory scoring system for predicting outcomes in newly diagnosed diffuse large B-cell lymphoma patients

Abstract: Diffuse large B-cell lymphoma (DLBCL) is the most common aggressive non-Hodgkin lymphoma and often carries a poor prognosis. Current prognostic systems such as the…

Date: 2025-07-28

Global, regional, and national anemia burden among women of reproductive age (15–49 years) from 1990 to 2021: an analysis of the Global Burden of Disease Study 2021

Abstract: Anemia remains a significant global health challenge, disproportionately affecting women of reproductive age (WRA, 15 to 49 years) due to physiological and socioeconomic…

Date: 2025-07-28

Downregulated PTEN and aberrant JAK–STAT signal pathway in essential thrombocythemia patients

Abstract: Background: Essential thrombocythemia (ET) is one of the Philadelphia-negative (Ph?) classical myeloproliferative neoplasms (MPNs), characterized by increased…

Date: 2025-05-23

RET fusion driven (RETfus+) non-small cell lung cancer: a comprehensive genomic profiling study with histologic correlation

Abstract: Background: Fusion of the RET gene resulting in clinically significant Genomic Alteration (GA) occur in 1-2% of NSCLC in the United States and has emerged as a major…

Date: 2025-05-16

Dynamic ferritin levels and survival outcomes in secondary hemophagocytic syndrome: a comprehensive analysis

Abstract: Background: Hemophagocytic syndrome (HPS) is a life-threatening condition characterized by excessive immune activation and cytokine release. Reliable prognostic markers…

Date: 2025-05-15