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Chloride channel-3 regulates sodium-iodide symporter expression and localization in the thyroids of mice on a high-iodide diet

Abstract: Introduction: Certain chloride channels and H+/Cl? antiporters, such as chloride channel 3 (ClC-3), are expressed at the apical pole of thyrocytes, facilitating iodide…

Date: 2025-03-21

Glypican-4 trajectory predicts the risk of gestational diabetes mellitus and the requirement for insulin therapy during pregnancy

Abstract: Background: Gestational diabetes mellitus (GDM), characterized by the onset of glucose intolerance during pregnancy, results in a series of complications for maternal…

Date: 2025-03-21

Circadian rhythm related genes identified through tumorigenesis and immune infiltration-guided strategies as predictors of prognosis, immunotherapy response, and candidate drugs in skin cutaneous malignant melanoma

Abstract: Background: Skin cutaneous malignant melanoma (SKCM) is among the most aggressive forms of skin cancer, notorious for its rapid progression and poor prognosis under late…

Date: 2025-03-21

Effect of premature luteinizing hormone surge on pregnancy outcomes in intracytoplasmic sperm injection or in vitro fertilization cycles

Abstract: Background: A premature surge in luteinizing hormone (LH) during ovarian stimulation cycles between 12 and 25% has been commonly reported. However, there is still a lack…

Date: 2025-03-21

Association between catheter ablation and psychiatric disorder risk in adults with atrial fibrillation: a multi-institutional retrospective cohort study

Abstract: Background: Given that atrial fibrillation (AF) s associated with a high risk of psychiatric disorders, understanding the potential benefits of catheter ablation is…

Date: 2025-03-21

Ecological Momentary Assessment of emotional dysregulation and outbursts among youth with ADHD: a feasibility study of a biomarker-driven predictive algorithm in the special education pre-K and early childhood classroom settings

Abstract: Background: Attention Deficit Hyperactivity Disorder (ADHD) among children younger than 6 years is quite impairing, nearly half these youth with ADHD experience school…

Date: 2025-03-21

The mediating role of biological age in the association between dietary index for gut microbiota and sarcopenia

Abstract: Background: Dietary Index of Gut Microbiota (DI-GM) is a newly proposed comprehensive metric for assessing dietary quality in relation to gut microbiota composition.…

Date: 2025-03-21

Pseudomonas aeruginosa enhances anti-PD-1 efficacy in colorectal cancer by activating cytotoxic CD8+ T cells

Abstract: Background: Immune checkpoint therapy for colorectal cancer (CRC) has been found to be unsatisfactory for clinical treatment. Fecal microbiota transplantation (FMT) has…

Date: 2025-03-21

The impact of depression on the quality of life of lung cancer patients undergoing chemotherapy: mediating effects of perceived social support

Abstract: Background: Quality of life (QOL) in patients undergoing chemotherapy for lung cancer has been a key research area. Numerous studies have examined the relationships…

Date: 2025-03-21