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Celecoxib prevents malignant progression of smoking-induced lung tumors via suppression of the COX-2/PGE2 signaling pathway in mice

Abstract: Introduction: Lung cancer is characterized by a poor prognosis and is a significant comorbidity of chronic obstructive pulmonary disease (COPD). Therefore, effective…

Date: 2025-03-19

Adherence to the Mediterranean diet is associated with lower cancer-related fatigue: a cross-sectional analysis from NHANES 2017–2020

Abstract: Background and objectives: Cancer-related fatigue is a common and distressing symptom experienced by cancer patients, which may persist from the time of diagnosis to the…

Date: 2025-03-19

Construction of a predictive model for the efficacy of anti-VEGF therapy in macular edema patients based on OCT imaging: a retrospective study

Abstract: Background: Macular edema (ME) is an ophthalmic disease that poses a serious threat to human vision. Anti-vascular endothelial growth factor (anti-VEGF) therapy has…

Date: 2025-03-19

The strong correlation between visual function improvement and retinal microcirculation enhancement in glaucoma

Abstract: Introduction: This study aimed to investigate the alterations in retinal vessel density (VD) among glaucomatous patients following effective intraocular pressure (IOP)…

Date: 2025-03-19

The association between lipid accumulation product and osteoporosis in American adults: analysis from NHANES dataset

Abstract: Background: The Lipid Accumulation Product (LAP), a novel indicator of fat accumulation, reflects the distribution and metabolic status of body fat. This study aims to…

Date: 2025-03-19

Comprehensive analysis of the ischemic stroke burden at global, regional, and national levels (1990–2021): trends, influencing factors, and future projections

Abstract: Background and purpose: Estimating the global burden of ischemic strokes (IS) is crucial for enhancing prevention and control strategies.

Date: 2025-03-19

Association of acrylamide exposure with markers of systemic inflammation and serum alpha-klotho concentrations in middle-late adulthood

Abstract: Background: Acrylamide (AA) is a ubiquitous environmental contaminant linked to systemic inflammation and oxidative stress in animal studies; however, the…

Date: 2025-03-19

Association between Hemoglobin Glycation Index and In-Hospital all-cause mortality of patients with Congestive Heart Failure: a retrospective study utilizing the MIMIC-IV database

Abstract: Background: The aim of this study was to explore the relationship between the hemoglobin glycation index (HGI) of Congestive Heart Failure (CHF) patients and their risk…

Date: 2025-03-19

Association between neutrophil-to-lymphocyte ratio and all-cause and cardiovascular mortality among adults with cancer from NHANES 2005-2018: a retrospective cohort study

Abstract: Background: Evidence on the association between the neutrophil-to-lymphocyte ratio (NLR) and all-cause and cardiovascular disease (CVD) mortality in adults with cancer…

Date: 2025-03-18