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Identification and validation of endoplasmic reticulum stress-related diagnostic biomarkers for type 1 diabetic cardiomyopathy based on bioinformatics and machine learning

Abstract: Background: Diabetic cardiomyopathy (DC) is a serious complication in patients with type 1 diabetes mellitus and has become a growing public health problem worldwide.…

Date: 2025-03-18

Enhancing ophthalmology students’ awareness of retinitis pigmentosa: assessing the efficacy of ChatGPT in AI-assisted teaching of rare diseases—a quasi-experimental study

Abstract: Background: Retinitis pigmentosa (RP) is a rare retinal dystrophy often underrepresented in ophthalmology education. Despite advancements in diagnostics and treatments…

Date: 2025-03-18

Invivo and in vitro analyses of surface whitening in hydrophobic trifocal intraocular lenses

Abstract: Introduction: Transparency loss due to the whitening of trifocal hydrophobic intraocular lenses (IOLs) is a rare but poorly understood phenomenon. This study…

Date: 2025-03-18

A novel grid-assisted pie-crusting technique for achieving soft tissue balance in total knee arthroplasty

Abstract: Background: To evaluate the effectiveness of a novel grid-based pie-crusting technique for soft tissue release at different locations of the medial collateral ligament…

Date: 2025-03-18

Association between plain water intake and the risk of osteoporosis among middle-aged and elderly people in the United States: a cross-sectional study

Abstract: Background: The connection between plain water intake (PWI) and osteoporosis risk is still unclear. The investigation aimed to identify the relationship between PWI and…

Date: 2025-03-18

Tumour necrosis factor-? induces macromolecule translocation in HIV-derived duodenal organoids

Abstract: Background: Disease progression from human immunodeficiency virus (HIV) infection to acquired immunodeficiency syndrome (AIDS) is marked by chronic immune activation,…

Date: 2025-03-18

Prevalence and incidence of multiple sclerosis in Bulgaria

Abstract: Background: Multiple sclerosis (MS) is a chronic, inflammatory, autoimmune, demyelinating and neurodegenerative disease of the central nervous system that primarily…

Date: 2025-03-18

Prediction model for severe autoimmune encephalitis: a tool for risk assessment and individualized treatment guidance

Abstract: Background: Severe autoimmune encephalitis (AE) can cause significant neurological deficits, status epilepticus, status dystonicus, and even death, which can be…

Date: 2025-03-18

Characterizing HLA-A2-restricted CD8+ T-cell epitopes and immune responses to Omicron variants in SARS-CoV-2-inactivated vaccine recipients

Abstract: Introduction: Recent surveillance has identified the emergence of the SARS-CoV-2 Omicron ariant, which exhibits the ability to evade multiple neutralizing antibodies…

Date: 2025-03-18

Direct economic burden of acute coronary syndromes in the Portuguese National Health Service—facts and trends between 2002 and 2022

Abstract: Aim: We estimated the average direct cost per Acute Coronary Syndromes (ACS) in-patient episodes by diagnosis, namely ST-elevation myocardial infarction (STEMI), non-ST…

Date: 2025-03-18