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The systemic immune-inflammation index is superior to predicting clinical remission and relapse for ulcerative colitis patients treated with vedolizumab

Abstract: Background: Vedolizumab (VDZ), a novel biologic targeting ?4?7 integrin, is safe and effective for the treatment of patients with ulcerative colitis (UC). The objective…

Date: 2025-03-13

Prospective study on diagnostic efficacy of targeted NGS vs. traditional testing for respiratory infections in myelosuppressed hematology patients

Abstract: Background: Respiratory tract infections are a significant complication in myelosuppressed hematological patients, especially those with myelosuppression. Traditional…

Date: 2025-03-12

Zanubrutinib plus R-CHOP improves the treatment effect of newly diagnosed diffuse large B cell lymphoma with double expression of MYC and BCL-2

Abstract: Background: Relevant studies have demonstrated the poor treatment outcomes and prognosis for double-expressor diffuse large B cell lymphoma (DE-DLBCL) in the rituximab…

Date: 2025-03-12

Inflammatory profiling and immune cell infiltration in dysthyroid optic neuropathy: insights from bulk RNA sequencing

Abstract: Background: Dysthyroid optic neuropathy (DON), the most severe complication of thyroid eye disease (TED), has unclear mechanisms and unsatisfactory treatment outcomes.…

Date: 2025-03-12

The impact of atopic dermatitis on caregivers’ quality of life in Ethiopia

Abstract: Background: Atopic dermatitis (AD) significantly impacts both the physical and psychological well-being of children and caregivers. As AD severity increases, so does its…

Date: 2025-03-12

Anti-CD137 agonist antibody–independent and clinically feasible preparation of tumor-infiltrating lymphocytes from soft tissue sarcoma and osteosarcoma

Abstract: Background: Tumor infiltrating lymphocytes (TILs) therapy has been proved for treatment of metastatic melanoma and is under investigation for other types of solid…

Date: 2025-03-12

Risk factors for mortality in patients with primary biliary cholangitis: a nomogram to predict 5-year survival

Abstract: Aim: The issue of transplant-free survival rate (OS) among patients with primary biliary cholangitis (PBC) remains a persistent concern. In predicting the long-term OS…

Date: 2025-03-12

Mental health of general practitioners and family medicine specialists 2?years into the COVID-19 pandemic

Abstract: Introduction: The COVID-19 pandemic has significantly impacted general medical practice by altering work structures and increasing teamwork while also adversely…

Date: 2025-03-12

Exploring barriers and facilitators to water availability and accessibility, and potential strategies for improving water accessibility and children’s intake in family childcare homes: a qualitative study

Abstract: Background: Children in the U.S. drink too little water and too much juice and sugar sweetened beverages. Inadequate access to drinking water in locations where children…

Date: 2025-03-12