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Integrating HIV prevention with family planning services for adolescent girls and young women in Uganda: perspectives of adolescent girls and young women, health care providers, and policymakers

Abstract: Introduction: Persistently high HIV incidence among women, especially adolescent girls and young women (AGYW), have drawn the attention of national policymakers, donors,…

Date: 2025-02-24

The changes of NLRs family members in the brain of AD mouse model and AD patients

Abstract: Introduction: Alzheimer’s disease (AD), a prevalent neurodegenerative disease, is primarily characterized by progressive neuron loss and memory impairment. NOD-like…

Date: 2025-02-24

Exploring adolescents' mental health in Kampala, Uganda in the context of COVID-19: a mixed methods study

Abstract: Background: Urban areas, particularly in developing nations like Uganda, face heightened risks due to poverty, unemployment, and environmental challenges, intensifying…

Date: 2025-02-24

Engineered exosomes restore miR-508-5p expression in uterine corpus endometrial carcinoma and reduce tumor progression and metastasis by targeting DLL3

Abstract: Introduction: Endometrial cancer (EC) is a growing global health concern. Understanding the molecular mechanisms driving EC is crucial for developing effective…

Date: 2025-02-24

Exploration of risk factors and characteristics of COVID-19 infection among patients with hematological malignancies in Suzhou, China: a retrospective study

Abstract: Background and aim: Patients diagnosed with cancer, particularly those with hematologic malignancies, frequently exhibit a state of immunosuppression. Currently, there…

Date: 2025-02-21

Risk stratification in neuroblastoma patients through machine learning in the multicenter PRIMAGE cohort

Abstract: Introduction: Neuroblastoma, the most prevalent solid cancer in children, presents significant biological and clinical heterogeneity. This inherent heterogeneity…

Date: 2025-02-21

Construction and evaluation of leukemia suicide risk predictive model based on SEER database

Abstract: Background: A marked increase in suicide rate has been detected among individuals diagnosed with leukemia. Our research aimed to develop a predictive model intended for…

Date: 2025-02-21

Outcomes of transsphenoidal surgery for pituitary adenomas in Spain: a retrospective multicenter study

Abstract: Background: The outcomes of transsphenoidal surgery (TSS) for pituitary adenoma (PA) depend on many factors, including the availability of an expert team and the volume…

Date: 2025-02-21

Two rare mutations in homozygosity synergize to silence TREX1 in Aicardi-Goutières syndrome

Abstract: Background: Aicardi-Goutières syndrome (AGS) is a rare monogenic type I interferonopathy characterized by dysregulated inflammation and tissue damage that primarily…

Date: 2025-02-21

Use of CatBoost algorithm to identify the need for surgery in infants with necrotizing enterocolitis

Abstract: Background: Early identification of infants with necrotizing enterocolitis (NEC) at risk of surgery is essential for an effective treatment. This study aims to clarify…

Date: 2025-02-21