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Dual oncogenic role of RNF220 in AML: linking metabolic rewiring to cell proliferation and immune evasion

Abstract: Acute myeloid leukemia (AML) remains a clinical challenge with suboptimal long-term survival. While circular RNAs derived from the RNF220 host gene have been implicated…

Date: 2025-11-27

Low-dose glucocorticoid improves progression-free survival of children with B cell acute lymphoblastic leukaemia following chimeric antigen receptor T-cell therapy

Abstract: The prognostic impact of immunosuppressant therapies for cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS), along with…

Date: 2025-11-27

Weight loss increases circadian gene expression and emotional well-being in individuals with obesity

Abstract: Obesity is associated with disruptions in circadian rhythms and emotional well-being that can contribute to metabolic and psychological health issues. This study aimed…

Date: 2025-11-27

The frequency of polycystic ovary syndrome in women with prediabetes compared with normoglycemic women

Abstract: To determine rate of polycystic ovary syndrome (PCOS) and its related features in women with prediabetes. Of 3465 consecutive women applied between 2021 and 2023, 3218…

Date: 2025-11-27

Correlation of body compositions and bone mineral density in postmenopausal women with different body mass index

Abstract: The association between obesity and bone mineral density (BMD) is controversial. Body composition parameters have been found to be strongly correlated with BMD. Body…

Date: 2025-11-27

Exploring the relationship of triglyceride to high-density lipoprotein cholesterol and the triglyceride-glucose index with white matter hyperintensities in individuals with type 2 diabetes: a cross-sectional analysis

Abstract: Previous studies have shown that the triglyceride-glucose index (TyG) is associated with white matter hyperintensities (WMH) in a healthy population, acting as a marker…

Date: 2025-11-27

The predictive value of 24-hour urinary calcium for kidney stone risk in primary hyperparathyroidism: insight from a retrospective study of parathyroid adenoma cases

Abstract: Primary hyperparathyroidism (PHPT) is associated with an increased risk of kidney stones. However, the clinical utility of 24-hour urinary calcium (24h-UCa) as a…

Date: 2025-11-27

Association between the triglyceride-glucose index and carotid plaque progression in patients with type 2 diabetes mellitus: a retrospective cohort study

Abstract: The triglyceride-glucose (TyG) index is a novel marker of insulin resistance associated with carotid vascular disease; however, its role in type 2 diabetes mellitus…

Date: 2025-11-27

Associations between neutrophil-lymphocyte ratio with all-cause mortality, major adverse vascular events and progression of diabetic kidney disease in type 2 diabetes mellitus

Abstract: The neutrophil lymphocyte ratio (NLR) is a readily accessible marker of systemic inflammation. This study evaluated the association between NLR with all-cause mortality,…

Date: 2025-11-27

Relationship between the Chinese visceral adiposity index and gout in individuals with type 2 diabetes mellitus: a cross-sectional population-based study

Abstract: Visceral adiposity indices have recently attracted considerable attention in metabolic and cardiovascular research. Here, the link between the Chinese Visceral Adiposity…

Date: 2025-11-27