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The real-world safety of Ofatumumab: a pharmacovigilance analysis based on the FDA adverse event reporting system

Abstract: Background: Ofatumumab is a humanized monoclonal antibody that targets CD20-positive B cells. It was approved by the FDA in 2020 for the treatment of relapsing multiple…

Date: 2025-01-23

Pre-pandemic cross-reactive antibody and cellular responses against SARS-CoV-2 among female sex workers in Dakar, Senegal

Abstract: Background: The COVID-19 pandemic had a severe impact globally, yet African populations exhibited unexpectedly lower rates of severe disease and mortality. We…

Date: 2025-01-23

Causal relationship between immune cells and risk of heart failure: evidence from a Mendelian randomization study

Abstract: Background: Heart failure (HF) is a clinical syndrome resulting from structural damage or dysfunction of the heart. Previous investigations have highlighted the critical…

Date: 2025-01-23

Decreased vitamin D increase the risk for subclinical hypothyroidism in individuals with T2DM: a cross-sectional study

Abstract: Background: Vitamin D is crucial for regulating calcium and phosphorus metabolism. More studies have revealed its role in chronic diseases. Our study aimed to examine…

Date: 2025-01-22

Predicted indirectly recognizable HLA epitopes scores and clinical outcomes after haploidentical stem cell transplantation in pediatric patients with relapsed neuroblastoma

Abstract: Introduction: The Predicted Indirectly ReCognizable HLA Epitopes (PIRCHE) model is a recently developed algorithm that predicts indirect T-cell recognition by…

Date: 2025-01-22

Comparison of thromboelastographic profiles and clinical characteristics in children with severe Mycoplasma pneumoniae pneumonia

Abstract: Background: This study aimed to compare Thromboelastographic (TEG) profiles and clinical characteristics between severe Mycoplasma pneumoniae (MP) pneumonia patients…

Date: 2025-01-22

Clinical presentations and outcomes of celiac disease in children and adolescents at a tertiary care center in Lebanon

Abstract: Introduction: Studies on the clinical presentation of celiac disease and its impact on the growth of children in Lebanon are limited. The aim of this…

Date: 2025-01-22

Identification and verification of autophagy-related gene signatures and their association with immune infiltration and drug responsiveness in epilepsy

Abstract: Background: Epilepsy, a common neurological disorder, is characterized by susceptibility to recurrent seizures. Increasing evidence suggests that autophagy plays a…

Date: 2025-01-22

Association of preoperative ultrasonographic parameters of the contralateral kidney with long-term serum creatinine in cats treated for unilateral ureteral obstruction

Abstract: Introduction: Prediction of renal recovery after surgical management of feline unilateral ureteral obstruction (UO) is crucial to guide therapeutic decisions, but…

Date: 2025-01-22

Sequential transcriptome profiling: comparative analysis of normal and canine lymphoma preceding detailed T-cell and B-cell subtype comparison

Abstract: Introduction: As the lifespan of companion animals extends, the incidence of tumor also increases. Among these tumors, lymphoma is reported as the most prevalent…

Date: 2025-01-22