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Cardiovascular toxicity of tisagenlecleucel in children and adolescents: analysis of spontaneous reports submitted to FAERS

Abstract: Background: The advent of tisagenlecleucel has been a major advance in the pharmacological treatment of relapsed/refractory B-cell acute lymphoblastic leukemia in…

Date: 2025-01-22

Association between triglyceride-glucose index and all-cause mortality in critically ill patients with acute myocardial infarction: analysis of the MIMIC-IV database

Abstract: Background: Currently, the clinical evidence regarding the prognostic significance of the TyG index in acute myocardial infarction (AMI) patients remains unclear. Our…

Date: 2025-01-22

Prognostic value of inflammatory markers for all-cause mortality in patients with acute myocardial infarction in the coronary care unit: a retrospective study based on MIMIC-IV database

Abstract: Background: Acute myocardial infarction (AMI) is prevalent and perilous, leading to mortality and disability in the coronary care unit (CCU). This paper was to verify…

Date: 2025-01-22

Knowledge, attitudes and practice toward refractive errors management among left-behind children of migrant workers

Abstract: Background: This study aimed to access knowledge, attitudes and practice (KAP) regarding refractive errors (RE) management among the left-behind children of migrant…

Date: 2025-01-21

Low back pain trends attributable to high body mass index over the period 1990–2021 and projections up to 2036

Abstract: Background: High body mass index (BMI) is a crucial determinant in low back pain (LBP) incidence and progression. However, the effect of increased BMI on LBP has been…

Date: 2025-01-21

Investigating the potential immunomodulatory effects of commercial oral probiotic supplements on equine gastrointestinal tract barrier function

Abstract: Background: Oral probiotic dietary supplements are widely used in veterinary medicine, including in horses. It is hypothesized that the presence of probiotic strains can…

Date: 2025-01-21

Piloting an automated query and scoring system to facilitate APDS patient identification from health systems

Abstract: Introduction: Patients with activated PI3K? syndrome (APDS) may elude diagnoses for nearly a decade. Methods to hasten the identification of these patients, and other…

Date: 2025-01-21

Association of ERAP1 and ERAP2 gene polymorphisms and ERAP2 protein with the susceptibility and severity of rheumatoid arthritis in the Ukrainian population

Abstract: Introduction: Rheumatoid arthritis (RA) is a long-term autoimmune disorder that primarily affects joints. Although RA is chiefly associated with HLA class II,…

Date: 2025-01-21

PCSK9-antibodies fail to block PCSK9-induced inflammation in macrophages and cannot recapitulate protective effects of PCSK9-deficiency in experimental myocardial infarction

Abstract: Background and aims: Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays a crucial role in cholesterol homeostasis by regulating low-density lipoprotein (LDL)…

Date: 2025-01-21