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Development of human innate immune responses in a humanized mouse model expressing four human myelopoiesis transgenes

Abstract: Background: Dysregulated innate immune responses underlie multiple inflammatory diseases, but clinical translation of preclinical innate immunity research in mice is…

Date: 2024-09-27

Acceptance and commitment therapy group protocol for caregivers of anxious youth: an open trial pilot study

Abstract: Introduction: Anxiety disorders are common, distressing, and impairing for children and families. Cognitive-behavioral interventions targeting the role of family…

Date: 2024-09-27

How the acceleration phase influences energy flow and the resulting joint moments of the throwing shoulder in the deceleration phase of the javelin throw

Abstract: Introduction: The throwing motion in the javelin throw applies high loads to the musculoskeletal system of the shoulder, both in the acceleration and deceleration…

Date: 2024-09-27

The impact of successful chronic total occlusion percutaneous coronary intervention on clinical outcomes: a tertiary single-center analysis

Abstract: Background: The benefit of chronic total occlusion (CTO)-percutaneous coronary intervention (PCI) is controversial because of a lack of high-quality evidence. We aim to…

Date: 2024-09-27

The doctor will not see you now: investigating the social determinants of specialist care using the Canadian Longitudinal Study on Aging (CLSA)

Abstract: Background: The Canada Health Act mandates universal access to medical services for all Canadians. Despite this, there are significant disparities in access based on…

Date: 2024-09-27

Myasthenia Gravis: utilising cross-platform quantitative content analysis to uncover and validate unmet needs

Abstract: Background: Recent years have seen a rapid growth in the number of online health communities targeted at patients with long-term conditions. Myasthenia Gravis (MG) is a…

Date: 2024-09-27

The causal relationship between immune cell traits and schizophrenia: a Mendelian randomization analysis

Abstract: Introduction: The complex and unresolved pathogenesis of schizophrenia has posed significant challenges to its diagnosis and treatment. While recent research has…

Date: 2024-09-27

Molecular landscape of kidney allograft tissues data integration portal (NephroDIP): a curated database to improve integration of high-throughput kidney transplant datasets

Abstract: Introduction: Kidney transplantation is the optimal treatment for end-stage kidney disease; however, premature allograft loss remains a serious issue. While many…

Date: 2024-09-27

Role of disulfidptosis in colorectal adenocarcinoma: implications for prognosis and immunity

Abstract: Background: Recent research has found a new way of cell death: disulfidptosis. Under glucose starvation, abnormal accumulation of disulfide molecules such as Cystine in…

Date: 2024-09-27