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Neutrophil-fibroblast crosstalk drives immunofibrosis in Crohn’s disease through IFN? pathway

Abstract: Introduction: Crohn’s disease (CD) is characterized by chronic inflammation and intestinal fibrosis leading to lifelong complications. However, the disease pathogenesis…

Date: 2024-09-13

Causal roles of circulating cytokines in sarcopenia-related traits: a Mendelian randomization study

Abstract: Background: Epidemiological and experimental evidence suggests that chronic inflammation plays an important role in the onset and progression of sarcopenia. However,…

Date: 2024-09-13

Dissecting the causal links between gut microbiome, immune traits and polyp using genetic evidence

Abstract: Background: Previous research has demonstrated an association between gut microbiota and immune status with the development of several diseases. However, whether these…

Date: 2024-09-13

The association between oxidative balance score and muscular dystrophies

Abstract: Introduction: This research utilized data from the NHANES 2011–2018 study to investigate the connection between the Oxidative Balance Score (OBS) and muscular…

Date: 2024-09-13

Supplementation with Lactobacillus helveticus NS8 alleviated behavioral, neural, endocrine, and microbiota abnormalities in an endogenous rat model of depression

Abstract: Introduction: Major depressive disorder is a condition involving microbiota–gut–brain axis dysfunction. Increasing research aims to improve depression through gut…

Date: 2024-09-13

Finite element analysis of dental structures: the role of mandibular kinematics and model complexity

Abstract: Introduction: This study observed the consequences of integrating mandibular kinematics in maxillary and mandibular teeth contact in a finite element analysis (FEA), and…

Date: 2024-09-12

Digital Spatial Profiling identifies distinct patterns of immuno-oncology-related gene expression within oropharyngeal tumours in relation to HPV and p16 status

Abstract: Background: The incidence of oropharyngeal cancer (OPC) is increasing, due mainly to a rise in Human Papilloma Virus (HPV)-mediated disease. HPV-mediated OPC has…

Date: 2024-09-12

Deciphering the role of tryptophan metabolism-associated genes ECHS1 and ALDH2 in gastric cancer: implications for tumor immunity and personalized therapy

Abstract: Background: Tryptophan Metabolism-associated Genes (TMGs), such as ECHS1 and ALDH2, are crucial in cancer progression through immunosuppressive mechanisms, particularly…

Date: 2024-09-12