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Acetylcytidine modification of DDX41 and ZNF746 by N-acetyltransferase 10 contributes to chemoresistance of melanoma

Abstract: Background: Rapidly developed chemoresistance to dacarbazine (DTIC) is a major obstacle in the clinical management of melanoma; however, the roles and mechanisms of…

Date: 2024-08-23

The incidence and risk factors of depression across six time points in the perinatal period: a prospective study in China

Abstract: Introduction: Perinatal depression (PND) affects approximately 15%–20% of women. This study aimed to determine the incidence of PND and identify risk factors.

Date: 2024-08-23

Overgeneralization of conditioned fear in patients with social anxiety disorder

Abstract: Introduction: While abnormal responses to threat, including overgeneralization to conditioned fear, have been postulated to play a critical role in pathological anxiety,…

Date: 2024-08-23

Tolerance to induced astigmatism of patients with trifocal or extended depth of focus intraocular lens implantation

Abstract: Background: Residual astigmatism is common after cataract surgery involving implantation of an intraocular lens, yet the tolerance of presbyopia-correcting intraocular…

Date: 2024-08-23

Study on the effect factors of discharge readiness of total hip arthroplasty patients

Abstract: Introduction: In order to explore the correlation between discharge readiness and Harris score or self-care ability of patients undergoing total hip arthroplasty (THA)…

Date: 2024-08-23

HMGB2 drives tumor progression and shapes the immunosuppressive microenvironment in hepatocellular carcinoma: insights from multi-omics analysis

Abstract: Background: Hepatocellular carcinoma (HCC) poses a significant health burden globally, with high mortality rates despite various treatment options. Immunotherapy,…

Date: 2024-08-23

Individualized activity recommendation based on a physical fitness assessment increases short- and long-term regular physical activity in people with multiple sclerosis in a retrospective cohort study

Abstract: Background: Despite the evidence of beneficial effects of physical activity (PA), people with multiple sclerosis (pwMS) are less physically active than the general…

Date: 2024-08-23

Prospective nutrition-inflammation markers for predicting early stoma-related complications in patients with colorectal cancer undergoing enterostomy

Abstract: Background: Enterostomy is important for radical resection of colorectal cancer (CRC). Nevertheless, the notable occurrence of complications linked to enterostomy…

Date: 2024-08-23