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Gut microbiota 16S rRNA profiling with plasma and urine metabolomics in vestibular migraine

Abstract: Vestibular migraine (VM) pathophysiology remains unclear, with research often extrapolating from migraine (M) studies. The microbiota-gut-brain axis represents a novel…

Date: 2026-03-19

A conserved monocyte activation program links brain injury to systemic immune adaptation and clinical outcomes

Abstract: Systemic immune dysregulation after traumatic brain injury (TBI) contributes to secondary complications and influences long-term recovery, yet the cellular and molecular…

Date: 2026-03-19

Endotoxin tolerance enhances breast cancer aggressiveness and alters inflammatory marker expression in tumor and spleen of mice

Abstract: Endotoxin tolerance (ET) is an immunological state in which repeated exposure to endotoxins such as lipopolysaccharide (LPS) leads to reprogramming of the immune system…

Date: 2026-03-19

Estimating time since influenza virus exposure using single-cell proteomic data

Abstract: Determining when the onset of a respiratory infection occurred is important for effective clinical management and can aid in mapping transmission events. However,…

Date: 2026-03-19

B-type natriuretic peptide attenuates TLR-induced cytokine and chemokine secretion in monocyte-derived Langerhans cells

Abstract: B-type natriuretic peptide (BNP) is a well-known cardiac hormone and biomarker of heart failure, but emerging evidence suggests that it also possesses immunomodulatory…

Date: 2026-03-19

Developing a new assessment model for systemic lupus erythematosus disease activity based on a case cohort

Abstract: To develop and validate a novel SLE disease activity scoring model designed to enhance diagnostic capability for moderate-to-severe disease activity in SLE patients…

Date: 2026-03-19

Morphology-based cytogenetic risk prediction in multiple myeloma from bone marrow smears

Abstract: Cytogenetic abnormalities determine prognosis and treatment selection in multiple myeloma (MM). However, genetic testing via fluorescence in situ hybridization remains…

Date: 2026-03-18

Single-cell sequencing reveals dynamic immune features of paraneoplastic pemphigus in a patient with follicular lymphoma

Abstract: Paraneoplastic pemphigus (PNP) is a highly fatal autoimmune blistering disease that commonly occurs in patients with underlying benign or malignant neoplasms. It poses…

Date: 2026-03-18

Cardiorenal risk stratification in high-risk type 2 diabetes using a simple clinical score: findings from the ELIXA trial

Abstract: Early identification of patients with high cardiorenal risk and timely targeted interventions are critical in managing type 2 diabetes (T2D). Although we previously…

Date: 2026-03-18

Impact of testosterone-based gender-affirming hormone therapy on toll-like receptor transcript levels and peripheral blood leukocyte counts in transmasculine individuals

Abstract: Sex differences in immune responses are partly attributed to sex hormones, with testosterone generally associated with dampened immune responses. However, the specific…

Date: 2026-03-18