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Timing of coffee consumption and insulin resistance: evidence from human and animal studies

Abstract: The role of coffee consumption timing in insulin resistance (IR), a key driver of cardiovascular-metabolic diseases, remains unclear. This study aimed to investigate the…

Date: 2026-03-13

Familial patterns of immune dysregulation in CVID: insights from B- and T-cell phenotyping and antibody profiling

Abstract: Common Variable Immunodeficiency (CVID) is a heterogeneous immune disorder characterized by a broad range of clinical manifestations. Its etiology is not yet fully…

Date: 2026-03-13

Beyond the triglyceride-glucose index, the cholesterol- high-density lipoprotein -glucose index as a superior predictor for diabetes risk in patients with major adverse cardiovascular events: dual evidence from the CHARLS database and real-world data

Abstract: To compare the predictive value of the cholesterol-high-density lipoprotein-glucose (CHG) index versus the triglyceride-glucose (TyG) index for new-onset diabetes in…

Date: 2026-03-12

Distinct diversity of skin cell populations of rhinophyma and hypertrophic scar illustrated by scRNA-seq

Abstract: The clinical manifestations and presentation of rhinophyma closely resemble those of hypertrophic scar tissue, both presenting as firm, fibrotic growths. Despite this…

Date: 2026-03-12

Spatial transcriptomic profiling reveals body site-specific inflammatory differences in psoriasis lesions

Abstract: Psoriasis is a common chronic inflammatory skin disease. Treatments lead to Q6 substantial improvement of most psoriasis plaques. However, it can be challenging to reach…

Date: 2026-03-12

A U-shaped association between sleep duration and depression in adult prescription opioid users

Abstract: The objective of this study was to investigate the correlation between sleep duration and depression in adult prescription opioid users. Data on adults who had recently…

Date: 2026-03-12

General anesthesia vs. non-general anesthesia for elderly stroke patients treated with mechanical thrombectomy

Abstract: This study aimed to compare the impact of general anesthesia (GA) versus non-GA on functional outcomes in elderly patients undergoing endovascular thrombectomy (EVT) for…

Date: 2026-03-12

Artificial intelligence-based endoscopic ultrasonography model for detecting the origin layer of gastric subepithelial lesions

Abstract: Gastric subepithelial lesions (SELs) are typically covered by intact mucosa, which challenges the determination of their layer of origin under conventional endoscopy.…

Date: 2026-03-12

Trends and disparities in skin malignant neoplasm mortality in the United States: a 22-year trend analysis based on CDC WONDER Data (1999-2020)

Abstract: Skin malignant neoplasms are common malignancies worldwide, with epidemiological characteristics showing significant geographical and demographic disparities. This study…

Date: 2026-03-11

Metabolic syndrome and the risk of perioperative ischemic stroke in non-cardiac surgery: a case-control retrospective study

Abstract: Perioperative ischemic stroke (PIS), although rare, is a devastating complication following surgery. Metabolic syndrome (MetS), also known as insulin resistance…

Date: 2026-03-11