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AGR2 promotes tumor progression by regulating macrophage polarization via the CD98hc-xCT/p-ERK pathway

Abstract: Anterior gradient 2 (AGR2) contributes to tumorigenesis, yet its function within the tumor microenvironment (TME) and in macrophage polarization remains unclear. This…

Date: 2026-02-26

Beneficial effects of upadacitinib on a subgroup of patients with atopic dermatitis and hidradenitis suppurativa: a multicenter, real-world retrospective study

Abstract: Although AD and HS are significantly different clinically, they share common systemic comorbidities and some immunological pathways. The aim of this multicentric Italian…

Date: 2026-02-25

IgE-defined endotypes reveal distinct clinical profiles of prurigo nodularis compared with atopic dermatitis: a multicenter study in China

Abstract: Prurigo nodularis (PN) is a chronic inflammatory dermatosis that often coexists with atopic dermatitis (AD) but represents a distinct entity. Evidence directly comparing…

Date: 2026-02-25

Cross-tissue integrative transcriptomic and multimodal analyses suggest shared immune signatures linking lupus nephritis and cutaneous lupus erythematosus

Abstract: Lupus nephritis (LN) and cutaneous lupus erythematosus (CLE) are major organ manifestations of systemic lupus erythematosus (SLE), imposing significant health and…

Date: 2026-02-24

Could vector-derived cadherin mimicry contribute to pemphigus vulgaris? An immunogenetic and in silico study involving HLA-DRB104:02 and 14:01

Abstract: Pemphigus vulgaris (PV) is a potentially life-threatening autoimmune blistering disease characterized by autoantibodies directed against the desmosomal cadherins…

Date: 2026-02-18

Clinical characteristics, treatment patterns, and survival in mantle cell lymphoma: a real-world cohort

Abstract: Mantle cell lymphoma is a rare, typically aggressive B-cell non-Hodgkin lymphoma that often presents at an advanced stage and carries substantial long-term mortality…

Date: 2026-01-30

Investigating diet to control asparagine uptake as an adjunct to asparaginase treatment

Abstract: Ongoing refinements of multidrug regimens, and particularly the addition of L-asparaginase, resulted in an immediate gain in survival for pediatric acute lymphoblastic…

Date: 2026-01-30

Low-dose cyclophosphamide combined with standard immunosuppressive therapy improves early response rates in severe aplastic anemia

Abstract: Thrombopoietin receptor agonists combined with anti-thymocyte globulin (ATG) and cyclosporine (CsA) are the standard immunosuppressive therapy (IST) for severe/very…

Date: 2026-01-30

Impact of pneumatic tube vs. bicycle courier transport on platelet aggregation: influence of sex and diabetes

Abstract: Pneumatic tube (PT) transport can impact platelet function, often altering platelet aggregation. Consequently, manual transport is frequently recommended to mitigate…

Date: 2026-01-30

Traditional Chinese medicine-based visual assessment of tongue features associated with current cancer vs. no cancer history: a matched case-control study

Abstract: Cancer survivorship is increasing, and many people living with and beyond cancer seek supportive care such as Traditional Chinese Medicine (TCM), where tongue inspection…

Date: 2026-01-30