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Dupilumab for atopic manifestations in pediatric patients with inborn errors of immunity: efficacy and safety in a genetically diverse cohort

Abstract: Inborn Errors of Immunity (IEI) are monogenic disorders that predispose patients to infections, autoimmunity, atopy, and malignancies. Severe Th2-driven atopic…

Date: 2025-11-27

The effect of broccoli stem extract cream ( Brassica oleracea L.) on macular scars post-acne

Abstract: Post-acne macular scars often cause skin discoloration, affecting appearance and self-confidence. To address this issue, various topical therapies have been developed.…

Date: 2025-11-27

Efficiency of the Sensory Mapping Score for Hansens’s disease diagnosis and follow-up: a functional cure criterion?

Abstract: Current operational criteria for Hansen’s disease (HD), which are primarily based on lesion count and fixed-duration multidrug therapy, tend to overlook the neurological…

Date: 2025-11-27

Yes-associated protein regulates autophagy to restore skin barrier function in atopic dermatitis

Abstract: Atopic dermatitis (AD) is characterized by skin barrier dysfunction and inflammation.This study explored the relationship between Yes-associated protein (YAP)…

Date: 2025-11-27

Beyond the skin: immunological profiles and infectious complications in ALOX12B-associated autosomal recessive congenital ichthyosis

Abstract: Pathogenic variants in ALOX12B , a crucial enzyme involved in epidermal lipid processing, are among the most common causes of autosomal recessive congenital ichthyosis…

Date: 2025-11-27

Neuromedin B identified as a therapeutic target for atopic dermatitis: evidence from Mendelian randomization and PCR validation

Abstract: Atopic dermatitis (AD) is a long-standing inflammatory dermatosis marked by intense itching and immune imbalance. Despite recent advances in targeted biologic therapies,…

Date: 2025-11-27

Comprehensive nursing intervention for postoperative scar management in preschool children with congenital melanocytic nevus

Abstract: Surgical excision of congenital melanocytic nevi (CMN) in preschool children is essential for minimizing oncogenic risk and improving cosmetic outcomes. However, such…

Date: 2025-11-27

Recovery time and associated factors of severe acute malnutrition in children aged 0–59?months admitted to referral hospitals in Tanzania: an institution-based prospective cohort study

Abstract: Malnutrition represents a pervasive global health challenge that severely impacts individuals of all ages. In Tanzania, severe acute malnutrition (SAM) is a critical…

Date: 2025-11-27

Spillover effects of military healthcare reform on civilian hospitals in China

Abstract: Military hospitals in China served a dual role, providing substantial healthcare to civilians alongside their primary mission of supporting military personnel. The 2015…

Date: 2025-11-27

Osteocalcin in human breast milk over the course of lactation

Abstract: Breast milk is the best nutrition for newborns. Its composition is dynamic and adapted to the newborn’s individual needs. A variety of bioactive compounds, including…

Date: 2025-11-27