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Inactivation of cofilin-1 in Mcpt5-Cre-nf-Cfl1 fl/fl mice prevents the formation of connective tissue mast cells without affecting basophils: a new tool to investigate the specific role of CTMCs in disease

Abstract: Actin-binding proteins play a critical role in regulating the dynamic rearrangement of the actin cytoskeleton, which is essential for maintaining cellular homeostasis…

Date: 2026-01-28

Construction of a nomogram model for predicting vaginal birth after induction of labor in pregnant women with fetal growth restriction at term

Abstract: The study aimed to develop and validate a predictive nomogram model of vaginal delivery in women with fetal growth restriction (FGR) who undergo labor induction. A…

Date: 2026-01-28

KCNB1 mutation impairs neuronal differentiation by disrupting gene expression temporal regulation and neuron-specific pathways

Abstract: This study aims to rigorously evaluate the consistency and reliability of a pluripotent stem cell (PSC) differentiation system and explore how the KCNB1 mutation…

Date: 2026-01-28

Effect of timely diagnosis and treatment on growth and body proportionality of children with congenital hypothyroidism

Abstract: Congenital hypothyroidism (CH) is a preventable cause of growth and neurodevelopmental deficits. In India, lack of universal newborn screening (NBS) delays diagnosis.…

Date: 2026-01-28

Trends and projections of dermatitis burden (1990–2040): a 2021 global burden of disease analysis

Abstract: Dermatitis is a major global public health challenge. This study evaluates its burden from 1990 to 2021 and projects future burden over the next 20?years. Data from the…

Date: 2026-01-28

Beyond the blues: marital dissatisfaction as a stronger predictor of postpartum depression than maternity blues among postpartum women: a prospective study in a Turkish cohort

Abstract: This study aimed to determine whether maternity blues (MBs) act as an independent predictor of postpartum depression (PPD), after controlling for key psychosocial…

Date: 2026-01-28

Autoimmune fibroinflammation in IgG4-related ophthalmic disease: TLR8-dependent signaling pathways and fibrotic remodeling revealed by proteomic profiling

Abstract: Immunoglobulin G4-related ophthalmic disease (IgG4-ROD) is an immune-mediated ocular condition characterized by tumefactive lesions with IgG4+ plasma cell infiltration,…

Date: 2026-01-28

Association between creatinine clearance and lumbar bone mineral density in Chinese patients with osteoporotic fractures: a retrospective cross-sectional study

Abstract: Creatinine clearance (CCR) is an important marker of renal function. The association between CCR and lumbar bone mineral density (BMD) in patients with osteoporotic…

Date: 2026-01-28

Identification of clinical predictors for functional recovery in patients with thoracolumbar fractures and incomplete spinal cord injury: an internally validated prediction model

Abstract: Accurate prediction of functional recovery after thoracolumbar fracture with incomplete spinal cord injury (SCI) remains challenging. We aimed to identify independent…

Date: 2026-01-28

A machine learning-driven prognostic model based on peripheral blood lymphocyte subsets in osteosarcoma

Abstract: The prognosis of osteosarcoma (OS) remains heterogeneous, and the prognostic value of peripheral blood lymphocyte subsets, analyzed through machine learning (ML), is not…

Date: 2026-01-28