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Maternal mixed UPD3 and a homozygous PLXNA1 c.2497G>C variant in a fetus with severe anomalies

Abstract: Non-invasive prenatal testing (NIPT) is widely used for screening common fetal aneuploidies such as trisomy 21 (T21), trisomy 18 (T18), and trisomy 13 (T13). However,…

Date: 2026-01-23

Young males in crisis: pathways, usage and acceptability of an online messenger based psychosocial counselling service

Abstract: Boys and young men face an elevated risk of mental health problems and suicidality, yet they remain less likely than their female peers to seek professional help. Online…

Date: 2026-01-23

Two-injection start regimen of long-acting aripiprazole for bipolar disorder: tips and tricks for better efficacy and tolerability

Abstract: To comparatively evaluate the efficacy and safety of the two aripiprazole long-acting injectable (LAI) initiation regimens, including one-injection start (OIS) regimen…

Date: 2026-01-23

Gut microbial alterations associated with the exacerbation of experimental autoimmune uveitis in PGRN-deficient mice

Abstract: Progranulin (PGRN) has been shown to play a protective role in the development of a variety of immune-mediated diseases, and the gut microbiome has been implicated in…

Date: 2026-01-23

Pleural effusion within 24 h of admission predicts severe hypertriglyceridemia-induced acute pancreatitis and organ failure: retrospective cohort of 296 patients

Abstract: Early risk-stratification in hypertriglyceridemia-induced acute pancreatitis (HTG-AP) is challenging within the first 24 h of admission. We assessed whether pleural…

Date: 2026-01-23

Explainable machine learning model to predict refeeding syndrome in patients with severe acute pancreatitis

Abstract: To construct and validate a risk prediction model for refeeding syndrome (RFS) in patients with severe acute pancreatitis (SAP), identify high-risk individuals before…

Date: 2026-01-23

Exosome-mediated bidirectional immune dysregulation in tuberculosis: proteomic profiling reveals strain-specific strategies of virulent H37Rv and attenuated H37Ra

Abstract: Tuberculosis (TB), caused by Mycobacterium tuberculosis ( Mtb ), remains a global health crisis, with drug resistance and immune evasion complicating control efforts.…

Date: 2026-01-23

Dynamic shifts in pathogen ecology of catheter-related bloodstream infections: temporal trends and ward-specific risk landscapes

Abstract: Catheter-related bloodstream infections (CRBSIs) represent a severe clinical complication with high mortality and pose a significant public health challenge due to…

Date: 2026-01-23

Influencing factors of initiation and maintenance of multidomain interventions in patients with mild cognitive impairment: a qualitative study

Abstract: Mild cognitive impairment (MCI) is a critical period for the prevention of dementia, and multidomain interventions can effectively delay and improve patients’ cognitive…

Date: 2026-01-23

Relationship between estimating glomerular filtration rate and cerebral large artery stenosis: a secondary analysis of a cross-sectional study

Abstract: Large cerebral artery stenosis (LCAS) is a risk factor for ischemic stroke; however, its relationship with kidney function remains unclear. This study aims to explore…

Date: 2026-01-23