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Real-world effectiveness and safety of imeglimin: a single-center retrospective cohort study in Japan

Abstract: This study aimed to evaluate the real-world effectiveness and safety of imeglimin in individuals with type 2 diabetes. We retrospectively reviewed 79 individuals (52…

Date: 2025-12-16

Extracorporeal photopheresis as a therapeutic approach for treatment resistant immune-related adverse events in anti-PD-1-treated melanoma patients

Abstract: Checkpoint inhibition induced immune-related adverse events (irAE) may be steroid-dependent or steroid-refractory and are associated with increased morbidity, mortality…

Date: 2025-12-16

High-altitude immune remodeling in children with Mycoplasma pneumoniae pneumonia: a multi-center transcriptome study

Abstract: A global outbreak of Mycoplasma pneumoniae pneumonia (MPP) emerged following the Corona Virus Disease 2019 (COVID-19) pandemic. Different altitudes significantly impact…

Date: 2025-12-16

Bridging the gap: effects of simulation-based OB/GYN training on skills and self-perception in final-year medical students

Abstract: Structured, simulation-based teaching is increasingly recognized as essential for clinical competence development. In Germany, however, practical training during the…

Date: 2025-12-16

Mediating effect of moral sensitivity in the relationship between mental workload and patient privacy protection among operating room nurses in China: a cross-sectional study

Abstract: Patient privacy protection is a fundamental ethical obligation in healthcare, particularly in operating rooms where anesthesia and complex surgical procedures increase…

Date: 2025-12-16

Public perceptions and emotional trends of psychotherapy: a 15-year analysis across English and Spanish language communities on X (twitter)

Abstract: Mental health disorders have been rising globally, and social media platforms provide a unique opportunity to examine public perceptions of psychotherapy. However,…

Date: 2025-12-16

Factors influencing patient decision-making on a multimodal precision medicine algorithm for depression: a qualitative European multicentre study of the PROMPT consortium

Abstract: Precision medicine promises to improve treatment outcomes by tailoring interventions to patients’ individual characteristics. However, the use of precision medicine…

Date: 2025-12-16

Medical-nursing integrated service model in ophthalmic outpatient care for intravitreal injections: a retrospective cohort study

Abstract: Outpatient intravitreal injections are widely utilized in contemporary ophthalmology practice. However, fragmented medical-nursing coordination and compressed clinical…

Date: 2025-12-16

IL-18 receptor axis in allergic conjunctivitis: a multi-omics study

Abstract: The pathophysiology of allergic conjunctivitis (AC) is not fully explained by the traditional Th2-centric model. This study aimed to identify AC-associated candidate…

Date: 2025-12-16

Utility of the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio in individuals with retinal vein occlusion

Abstract: The ratio of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol (NHHR) has recently been identified as a novel lipid marker for assessing…

Date: 2025-12-16