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Association between CRP-TyG index and hepatic synthetic function in post-myocardial infarction ICU patients

Abstract: To determine whether the CRP–TyG index (CTI)—a composite of systemic inflammation and insulin resistance—is independently associated with early hepatic synthetic…

Date: 2025-12-11

Development, validation, and web deployment of a rebleeding risk prediction model for acute non-variceal upper gastrointestinal bleeding in a Chinese population

Abstract: Acute non-variceal upper gastrointestinal bleeding (ANVUGIB) is a common life-threatening emergency. Despite advances in endoscopic hemostasis, the 7-day rebleeding rate…

Date: 2025-12-11

Helicobacter pylori infection and its impact on metabolic dysfunction-associated steatotic liver disease: a mediation analysis of neutrophil-albumin ratio

Abstract: Helicobacter pylori , a widely found bacterium, has been controversially connected to the risk of metabolic dysfunction-associated steatotic liver disease (MASLD). How…

Date: 2025-12-11

Glymphatic dysfunction in neuromyelitis optica spectrum disorder

Abstract: Neuromyelitis optica spectrum disorder (NMOSD) involves aquaporin-4-mediated astrocyte injury, potentially impairing the glymphatic system. We assessed glymphatic…

Date: 2025-12-11

Tertiary lymphoid structure drives allograft rejection via IFN-?-JAK-STAT-dependent atypical memory B cell differentiation

Abstract: Tertiary lymphoid structure (TLS) is a neogenized, ectopic lymphoid aggregate found in infected, autoimmune and tumour tissues with an activated adaptive immune…

Date: 2025-12-11

Fruquintinib saddles tumor immune tolerance by curbing pro-tumoral immature myeloid cell populations

Abstract: Myeloid-derived cells, particularly immature populations and tumor-associated macrophages, play a pivotal role in establishing immune tolerance and suppressing antitumor…

Date: 2025-12-11

Emotional intelligence and clinical decision-making confidence in nurses: the chain mediating effect of creative self-efficacy and self-directed learning

Abstract: Clinical decision-making competence underpins autonomous nursing practice. While external influences are documented, context-dependent psychological mechanisms linking…

Date: 2025-12-10

The actual experiences of nurses’ in implementing hypothermia prevention practices during post-anesthesia care unit: a qualitative study based on the PRECEDE-PROCEED model

Abstract: Hypothermia is one of the most common postoperative complications in the post-anesthesia care unit (PACU), and preventive measures are crucial for improving patient…

Date: 2025-12-10

Association between iron deficiency anemia and risk of hearing loss among female patients: a multi-institutional cohort study

Abstract: Iron deficiency anemia (IDA) represents the most prevalent nutritional deficiency worldwide, disproportionately affecting women of reproductive age. Emerging evidence…

Date: 2025-12-10

Preoperative insomnia exacerbates postoperative sleep fragmentation in elderly arthroplasty patients: a prospective cohort study

Abstract: Preoperative insomnia is prevalent among elderly arthroplasty patients, yet its impact on postoperative sleep disturbance (PSD) remains underexplored. This study…

Date: 2025-12-10