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Temporal trends and global burden of urolithiasis: a comparative analysis of incidence, prevalence, mortality, and disability-adjusted life years in China and globally from 1990 to 2021

Abstract: Urolithiasis significantly affects global health, contributing to substantial morbidity, healthcare costs, and reduced quality of life. Understanding temporal changes in…

Date: 2025-11-24

Plasma corin levels provide minimal prognostic utility in left atrial reverse remodeling after catheter ablation of atrial fibrillation: an observational study

Abstract: This study aims to assess the impact of plasma corin levels on left atrial reverse remodeling (LARR) in patients with atrial fibrillation (AF) after catheter ablation…

Date: 2025-11-24

Association between triglyceride glucose-body mass index and long-term adverse outcomes in individuals with heart failure: a retrospective cohort study

Abstract: Insulin resistance (IR) plays a pivotal role in the pathogenesis and progression of heart failure (HF), and may be exacerbated in advanced stages of HF, thereby…

Date: 2025-11-24

The oncometabolite R-2-hydroxyglutarate inhibits microglial activation via the FTO/NF-?B pathway

Abstract: Mutations in isocitrate dehydrogenase 1 (mIDH1) generate the oncometabolite (R)-2-hydroxyglutarate (R-2HG), which promotes tumorigenesis by inhibiting…

Date: 2025-11-24

Time series forecasting of red blood cell demand in hematology patients using SARIMA and exponential smoothing models: a retrospective analysis in a Chinese tertiary hospital

Abstract: Red blood cells (RBCs) infusion is very important for the treatment of hematology patients, but how to maintain a balanced state between the supply and demand of RBCs is…

Date: 2025-11-24

Associations between neutrophil-lymphocyte ratio with all-cause mortality, major adverse vascular events and progression of diabetic kidney disease in type 2 diabetes mellitus

Abstract: The neutrophil lymphocyte ratio (NLR) is a readily accessible marker of systemic inflammation. This study evaluated the association between NLR with all-cause mortality,…

Date: 2025-11-24

Hepcidin, ferroportin, and hemoglobin as predictors of iron deficiency anemia risk and perinatal outcomes in twin pregnancy

Abstract: This study investigated iron-deficiency anemia (IDA), third-trimester hepcidin and ferroportin levels, and perinatal outcomes in twin pregnancies. Pregnant women with…

Date: 2025-11-24

Drug-induced polycystic ovary syndrome: a real-world pharmacovigilance study based on the FAERS database

Abstract: Previous studies have shown an association between polycystic ovary syndrome (PCOS) and the use of various medications. However, there is still a lack of systematic…

Date: 2025-11-24

Clinical care processes for early postpartum haemorrhage diagnosis: a nested observational study within the E-MOTIVE trial

Abstract: Postpartum haemorrhage (PPH) is the leading cause of maternal mortality, particularly in low- and- middle-income countries. The E-MOTIVE trial demonstrated a 60%…

Date: 2025-11-24

Association between parity and adverse maternal and neonatal outcomes: a population-based cross-sectional study

Abstract: This study aimed to comprehensively assess the association between parity and adverse maternal and neonatal outcomes among Chinese women, particularly across different…

Date: 2025-11-24