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Carnosic acid alleviates 5-Fluorouracil chemoresistance and enhances CD8 + T cell cytotoxicity in gastric cancer by regulating the CXCL12/CXCR7 axis

Abstract: Key features of gastric cancer (GC) include its aggressive nature, high metastatic capability, and a tendency for relapse. While 5-fluorouracil (5-FU) remains a…

Date: 2026-09-08

Prognostic significance of peripheral immunity after thrombectomy in acute ischemic stroke: a retrospective study stratified by early post-EVT leukocyte count

Abstract: The prognostic relevance of early peripheral immune profiles after successful endovascular thrombectomy (EVT) remains incompletely characterized. We evaluated whether…

Date: 2026-09-08

Implementation of a standardized electronic medical record-integrated alternating hyperosmolar therapy protocol in neurocritical care: a single-center retrospective feasibility study

Abstract: Hyperosmolar therapy is a cornerstone of the medical management of cerebral edema and suspected intracranial hypertension. Despite widespread use of hypertonic saline…

Date: 2026-09-08

Age-dependent associations of peripheral inflammatory biomarkers with cognition and brain structural abnormalities in patients with Alzheimer’s disease and Alzheimer’s disease-related mild cognitive impairment

Abstract: Alzheimer’s disease (AD) is one of the most prevalent neurodegenerative conditions. Chronic peripheral inflammation has been implicated in the pathophysiology of AD.…

Date: 2026-09-08

IFN-?–dominant immune shift is associated with reduced protective ILC2 responses in chronic kidney disease

Abstract: Chronic kidney disease (CKD) progression is driven by an imbalance between inflammatory injury and tissue repair; however, the immune mechanisms that disrupt reparative…

Date: 2026-09-08

The epidemiological landscape of canine tumors in central Italy: animal cancer registry insights, distribution patterns, and incidence estimates

Abstract: Animal cancer registries (ACRs) monitor companion animal tumors, providing essential data for comparative oncology. Sharing domestic environments and possessing…

Date: 2026-09-08

High prevalence of gonadal dysfunction in pediatric sarcoma survivors: insights from hormonal and clinical markers

Abstract: A critical proportion of childhood bone and soft tissue sarcoma survivors experience some form of reproductive impairment. These findings underscore the increasing need…

Date: 2026-09-07

Early-onset CLL is characterized by enhanced microenvironment-driven metabolic fitness, increased proliferative bias, and accelerated disease progression

Abstract: Chronic lymphocytic leukemia (CLL) predominantly affects older adults; however, approximately 10% of patients are diagnosed at a younger age. Although overall survival…

Date: 2026-09-07

Cognitive impairment as a mediator of treatment discontinuation after intracerebral hemorrhage in acute leukemia

Abstract: Neurological deficits after spontaneous intracerebral hemorrhage (ICH) are linked to treatment discontinuation in acute leukemia patients, but underlying mechanisms are…

Date: 2026-09-07

Associations of polymorphisms in the myeloid immunoregulatory receptor gene MRC1 with expression and prognosis in acute myeloid leukemia

Abstract: Acute myeloid leukemia (AML) shows substantial biological and clinical heterogeneity that extends beyond leukemia-intrinsic genetic alterations. MRC1, which encodes the…

Date: 2026-09-07