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Global burden and epidemiological determinants of pulmonary arterial hypertension among women aged 55?years and older: a GBD 2023 analysis

Abstract: Pulmonary arterial hypertension (PAH) exhibits significant sex disparities; however, the impact on women aged ?55?years—a population-level proxy for postmenopausal women…

Date: 2026-09-07

Interim efficacy and preliminary survival outcomes of polatuzumab vedotin in combination for diffuse large B-cell lymphoma: a retrospective real-world study

Abstract: The standard first-line R-CHOP regimen achieves cure in only approximately 50% of patients. Polatuzumab vedotin (Pola) is a novel antibody-drug conjugate targeting the…

Date: 2026-09-04

Increased HIF-2? and CD105 (endoglin) expression is associated with poor differentiation in pheochromocytomas and paragangliomas

Abstract: Reliable biomarkers reflecting tumor biology and histopathological risk status in pheochromocytomas and paragangliomas (PPGL) remain limited. In this study, the…

Date: 2026-09-04

Plasma cortisol cut-off concentrations using the dexamethasone suppression test in patients with adrenal incidentalomas

Abstract: Assessment of cortisol secretion in patients with adrenal incidentalomas remains challenging. We evaluated the guideline-recommended cortisol cut-off value for cortisol…

Date: 2026-09-04

Adult psychological outcomes among women with different adolescent PCOS presentations

Abstract: Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder, often beginning in adolescence and associated with reproductive, metabolic, and psychological…

Date: 2026-09-04

Enzyme replacement therapy (ERT) combined with transient low-dose methotrexate (TLD-MTX) results in age- and disease-dependent immune profile changes in Infantile- vs. late-onset Pompe disease patients

Abstract: Transient low-dose methotrexate (MTX) induces long-term immune tolerance to enzyme replacement therapy (ERT) in Pompe disease; however, the underlying immunological…

Date: 2026-09-04

Decision-making process of exclusive breastfeeding at 6 months postpartum based on the COM-B model: a multicenter, cross-sectional study in Southeast China

Abstract: Exclusive breastfeeding (EBF) for the first 6 months is crucial for public health, yet EBF rates in China remain below the 50% target of “Healthy China 2030.” In…

Date: 2026-09-04

Clinical and molecular spectrum of Niemann-Pick disease type C patients in India

Abstract: Niemann–Pick disease type C (NPC) is a rare autosomal recessive lysosomal disorder caused by pathogenic variants in NPC1 or NPC2 , resulting in impaired intracellular…

Date: 2026-09-04

Herbal hot compress combined with bianstone warm ironing improves anxiety and cognitive impairment via gut-brain-HPA axis in pubertal mesenteric lymphadenitis rats

Abstract: Pediatric mesenteric lymphadenitis (ML) is characterized by persistent intestinal inflammation, intestinal barrier damage and excessive oxidative stress, which can…

Date: 2026-09-04

Construction and validation of a clinical predictive nomogram for subacute combined degeneration of the spinal cord based on LASSO regression

Abstract: This study aimed to develop and internally validate a nomogram prediction model for differentiating subacute combined degeneration of the spinal cord (SCD) from other…

Date: 2026-09-04