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Mechanisms of therapeutic antibodies immunogenicity: infliximab oligomeric aggregates increase T-cell response and uptake by dendritic cells involving mannose-sensitive receptor CD206

Abstract: Aggregation of therapeutic antibodies (Ab)s is now recognized as a major product-related factor associated with increased potential of immunogenicity. Regulatory…

Date: 2026-09-03

Knowledge-guided adaptive educational support for traditional Chinese medicine using large language models and knowledge graphs: integrating Confucian educational principles

Abstract: The Confucian principle of “teaching students in accordance with their aptitude” remains challenging to implement at scale in Traditional Chinese Medicine (TCM)…

Date: 2026-09-03

Development and external validation of a risk prediction model for hypertension among individuals with established hypothyroidism

Abstract: Hypothyroidism represents a multisystem endocrine disorder involving cardiovascular, renal, and metabolic alterations beyond thyroid hormone deficiency. However,…

Date: 2026-09-03

Traditional Chinese medicine reimbursement reform in China: implementation progress, policy constraints, and optimization strategies

Abstract: As the inheritance, innovation, and development of TCM advance, medical insurance reimbursement policies are intended to improve access, guide service structure, and…

Date: 2026-09-03

Development of a three-item short form of the EAT-10 for screening suspected dysphagia in hospitalized older adults: findings from a multicentre study

Abstract: To develop a three-item short form of the EAT-10 by identifying the smallest subset of items that preserves the screening performance of the full questionnaire in…

Date: 2026-09-03

An evaluation of pathology foundation models with weakly supervised learning for BRAF mutation prediction in melanoma whole slide images

Abstract: Melanoma is the most aggressive form of skin cancer, with around 40–50% of cases harbouring BRAF mutations that can be effectively targeted to improve patient outcomes.…

Date: 2026-09-03

A Bayesian network-based predictive model for gout onset risk: associations with traditional Chinese medicine constitution in hyperuricemic populations

Abstract: To develop a Bayesian network model for predicting gout onset risk in hyperuricemic individuals based on TCM body constitutions, quantify their influence, and provide…

Date: 2026-09-03

Group intervention for non-suicidal self-injury in college students guided by the Process Model of Emotional Regulation: a pilot randomized controlled trial

Abstract: Emotion regulation difficulties are a key risk factor for non-suicidal self-injury (NSSI) behaviors. This study aimed to reduce self-injurious behaviors among college…

Date: 2026-09-03

Prevalence of physical comorbidities and multimorbidity in Borderline Personality Disorder: risk factors and comparisons with schizophrenia and healthy controls

Abstract: Borderline personality disorder (BPD) is linked to a shorter life expectancy and poorer psychosocial functioning than seen in the general population, with outcomes…

Date: 2026-09-03

Work-related distress and professional quality of life in a medical-school workforce: a primary-care occupational-health perspective

Abstract: Work-related distress may present in primary care through nonspecific physical, psychological, or functional complaints. This study assessed professional quality of life…

Date: 2026-09-03