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Interpretable machine learning–based prediction of 90-day mortality after endovascular treatment in acute large vessel occlusion stroke

Abstract: Despite high recanalization rates after endovascular treatment (EVT) for acute ischemic stroke due to large vessel occlusion (AIS-LVO), 15%?20% of patients still die…

Date: 2026-09-03

Sequential NIHSS–NLR monitoring after endovascular thrombectomy: malignant cerebral oedema and inflammatory futility in a two-phase derivation study

Abstract: Successful reperfusion after endovascular thrombectomy (EVT) does not guarantee recovery. Malignant cerebral oedema (MCE) complicates approximately one in eight…

Date: 2026-09-03

Combination of tofacitinib and tacrolimus therapy in refractory interstitial lung disease associated with anti-synthetase syndrome: a case series of six patients

Abstract: This study aimed to assess the efficacy and safety of tofacitinib and tacrolimus (TAT) combination therapy for treating refractory interstitial lung disease (ILD)…

Date: 2026-09-03

Clinical phenotypes, endotypes, and biomarker profiles of immediate rituximab hypersensitivity reactions: a prospective pharmacovigilance study

Abstract: Rituximab (RTX) has been associated with immediate hypersensitivity reactions (HSRs) involving multiple phenotypes and endotypes. To characterize the clinical phenotypes…

Date: 2026-09-03

Prenatal maternal infection promotes maternal microchimeric cells to alter infection risk in male offspring

Abstract: Vertically transferred maternal cells or maternal microchimeric cells (MMCs) engraft the fetus and persist in offspring for long periods of time. How altered maternal…

Date: 2026-09-03

The effectiveness of the intervention model based on cognitive behavioral therapy in reducing risky sexual behaviors among MSM

Abstract: Based on CBT theory and the Internet, we established an intervention model targeting high-risk sexual behavior patterns in MSM. We then conducted a randomized controlled…

Date: 2026-09-03

Minocycline ameliorates CNS autoimmunity through restraint of CD4 + CD11bc + cells

Abstract: Minocycline is a tetracycline antibiotic with profound anti-inflammatory activity directed primarily against microglial cells and macrophages. Activation of nuclear…

Date: 2026-09-03

Complete blood count-derived myeloid-lymphoid inflammatory phenotype in rheumatoid arthritis complicated by acute myocardial infarction: an age- and sex-balanced retrospective study

Abstract: Rheumatoid arthritis (RA) is associated with excess cardiovascular morbidity, including acute myocardial infarction (AMI). Routine complete blood count (CBC)-derived…

Date: 2026-09-03

Tonsillar Tfh cells contribute to the pathogenesis of IgA nephropathy in collaboration with memory B cells

Abstract: Immunoglobulin A nephropathy (IgAN) is a chronic glomerular disease characterized by mesangial IgA deposition, which can progress to end-stage renal failure.…

Date: 2026-09-03

Development and external validation of a clinical-genetic risk identification model for rheumatoid arthritis-associated interstitial lung disease

Abstract: This study aimed to develop and externally validate a clinical risk identification model for prevalent rheumatoid arthritis-associated interstitial lung disease (RA-ILD)…

Date: 2026-09-03