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IL-17A inhibitors alleviate Psoriasis with concomitant restoration of intestinal/skin microbiota homeostasis and altered microbiota function

Abstract: Background: Disturbed gut microbiota and associated metabolic dysfunction exist in Psoriasis. Despite the growing use of interleukin-17 inhibitor (anti-IL17) therapy,…

Date: 2024-02-28

Brief research report: impact of vaccination on antibody responses and mortality from severe COVID-19

Abstract: Introduction: While it is established that vaccination reduces risk of hospitalization, there is conflicting data on whether it improves outcome among hospitalized…

Date: 2024-02-27

A novel NLRP3 inhibitor as a therapeutic agent against monosodium urate-induced gout

Abstract: Background: Since NEK7 is critical for NLRP3 inflammasome activation, NEK7 inhibitors could be employed as therapeutic agents against gout, a representative disease…

Date: 2024-02-27

Drug-target identification in COVID-19 disease mechanisms using computational systems biology approaches

Abstract: Introduction: The COVID-19 Disease Map project is a large-scale community effort uniting 277 scientists from 130 Institutions around the globe. We use high-quality,…

Date: 2024-02-27

Depression, professional self-efficacy, and job performance as predictors of life satisfaction: the mediating role of work engagement in nurses

Abstract: Background: The life satisfaction and job performance of nursing professionals are affected by a multitude of factors, including work engagement, self-efficacy, and…

Date: 2024-02-27

Gambling and virtual reality: unraveling the illusion of near-misses effect

Abstract: Introduction: Studying gambling behavior is a crucial element in reducing the impact of problem gambling. Nevertheless, most current research is carried out in…

Date: 2024-02-27

The socioeconomic burden of spinal muscular atrophy in Saudi Arabia: a cross-sectional pilot study

Abstract: Background: Spinal muscular atrophy (SMA) is a rare debilitating condition with a significant burden for patients and society. However, little is known about how it…

Date: 2024-02-27

Study on the trend of congenital heart disease inpatient costs and its influencing factors in economically underdeveloped areas of China, 2015–2020: a case study of Gansu Province

Abstract: Background: Economic data on congenital heart disease are scarce in economically underdeveloped areas of China. Therefore, this study aimed to shed light on the level…

Date: 2024-02-27

New-onset autoimmune disease after COVID-19

Abstract: Introduction: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) may trigger autoimmune disease (AD) through initial innate immune activation with subsequent…

Date: 2024-02-27

Identification of inhibitors from a functional food-based plant Perillae Folium against hyperuricemia via metabolomics profiling, network pharmacology and all-atom molecular dynamics simulations

Abstract: Introduction: Hyperuricemia (HUA) is a metabolic disorder caused by purine metabolism dysfunction in which the increasing purine levels can be partially attributed to…

Date: 2024-02-27