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Factors influencing oncologists’ decisions for germline BRCA testing and adjuvant therapy selection in HER2-negative early breast cancer

Abstract: With advances in targeted early breast cancer (eBC) treatment, research is needed to understand the factors influencing biomarker testing and respective treatment…

Date: 2026-09-03

Single-cell RNA sequencing reveals a pro-fibrotic epithelial subpopulation contributing to endometrial dysfunction in polycystic ovary syndrome

Abstract: Endometrial dysfunction in women with polycystic ovary syndrome (PCOS) significantly contributes to adverse pregnancy outcomes, including recurrent implantation failure…

Date: 2026-09-03

Longitudinal plasma and urinary SP-D and sRAGE during BEP chemotherapy in germ cell tumours

Abstract: Bleomycin-induced pulmonary toxicity remains a significant complication of curative BEP chemotherapy for germ cell tumours, and no validated circulating biomarker…

Date: 2026-09-03

Prognostic significance of pretreatment peripheral blood inflammatory biomarkers in elderly patients with locally advanced cervical cancer undergoing definitive chemoradiotherapy

Abstract: Systemic inflammatory response plays a critical role in tumor progression and immune evasion. Elderly patients with locally advanced cervical squamous cell carcinoma…

Date: 2026-09-03

Arginine is a protective factor for risk and prognosis of gastric cancer: an observational and Mendelian randomization study

Abstract: Previous research has indicated that certain amino acids possess anti-tumor properties. However, the impact of blood amino acid levels on the risk of gastric cancer…

Date: 2026-09-03

APIM-guided dyadic nursing after colorectal cancer surgery: a propensity score-matched cohort study

Abstract: Recovery after colorectal cancer surgery is influenced not only by patient symptoms but also by caregiver capacity, psychological distress, self-efficacy, and dyadic…

Date: 2026-09-03

The ALP score: a novel composite index for prognostic risk stratification to chemo-immunotherapy in advanced non-small cell lung cancer

Abstract: This study aimed to investigate the value of a novel composite index, the ALP score (calculated as the product of lymphocyte count and serum albumin), in predicting the…

Date: 2026-09-03

Development and validation of a novel nomogram integrating visceral-to-subcutaneous fat ratio and neutrophil-percentage-to-albumin ratio for overall survival in locally advanced rectal cancer undergoing neoadjuvant radiotherapy

Abstract: Emerging evidence suggests that neutrophils are preferentially recruited to visceral adipose tissue, connecting adipose distribution to systemic inflammation. Visceral…

Date: 2026-09-03

Sex differences in the associations of multidomain risk factor profiles with incident major adverse cardiovascular events

Abstract: Major adverse cardiovascular events (MACE) exhibit sex-specific disparities, but comprehensive analyses of combined genetic and clinical risk factor profiles across…

Date: 2026-09-03

PVN-centered multi-omics and single-cell analyses suggest shared inflammatory and immune features in acute myocardial infarction-associated ventricular arrhythmia and atrial fibrillation

Abstract: Acute myocardial infarction (AMI) increases the risk of arrhythmias, particularly ventricular arrhythmias (VA), and atrial fibrillation (AF) is also common after AMI.…

Date: 2026-09-03