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Long-term outcomes of early posterior scleral contraction for myopic macular retinoschisis in patients up to 30 years

Abstract: To evaluate the long-term anatomical and functional outcomes of early posterior scleral contraction (PSC) in patients up to 30 years with myopic macular retinoschisis…

Date: 2026-08-31

3D-printed patient-specific guides improve screw accuracy in upper cervical spine surgery: a comparative study

Abstract: To evaluate the feasibility and clinical efficacy of patient-specific 3D-printed guide plates for pedicle screw placement in the upper cervical spine, compared with the…

Date: 2026-08-31

Development of a predictive model for adverse outcomes after unilateral biportal endoscopic spine surgery in the treatment of lumbar disc herniation using six interpretable machine learning models

Abstract: This study aimed to develop and validate an interpretable machine learning model incorporating clinical and radiological features to predict the risk of adverse outcomes…

Date: 2026-08-31

Integrative multi-omics analysis prioritizes compartment-specific candidate targets of gut microbiota metabolites in diabetic kidney disease

Abstract: The gut-kidney axis has emerged as a critical area of investigation. However, the compartment-specific regulatory mechanisms of gut microbiota metabolites within the…

Date: 2026-08-31

Trends and forecasting of reported hepatitis B and hepatitis C incidence in Hainan Province, China, 2005–2020

Abstract: To assess long-term trends, seasonality, forecasts, and ecological associations with tourist visits for reported hepatitis B virus (HBV) and hepatitis C virus (HCV)…

Date: 2026-08-31

Potential hazard assessment of 6PPD-quinone in the context of ulcerative colitis: network toxicology, machine learning, transcriptomic analysis, and preliminary In vivo validation

Abstract: The ubiquitous tire-derived pollutant 6PPD-quinone (6PPD-Q) poses potential systemic health risks, yet its toxicological impact on the intestinal tract, particularly in…

Date: 2026-08-31

Transcriptomic analysis identifies FABP5 as a candidate regulator of lipid accumulation in metabolic dysfunction-associated fatty liver disease

Abstract: The pathogenesis of metabolic dysfunction-associated fatty liver disease (MAFLD) is very complex, which has not been fully revealed as so far. This study aimed to…

Date: 2026-08-31

Real-world deep brain stimulation programming practices for Parkinson’s disease in India: variability, technology adoption, and emerging trends from a multicentre clinician survey across India

Abstract: Deep brain stimulation (DBS) outcomes in Parkinson’s disease (PD) are strongly influenced by postoperative programming, yet real-world workflows and adoption of newer…

Date: 2026-08-31

Integrated multi-omics analysis indicates MARCO and ZBTB20 as candidate biomarkers in rheumatoid arthritis and tuberculosis

Abstract: Rheumatoid arthritis (RA) patients have a clearly increased possibility to develop tuberculosis (TB). However, the common molecular background, useful diagnostic…

Date: 2026-08-31

Vaccination of newborn monkeys with an influenza HA stem nanoparticle adjuvanted with R848 and AddaVax results in broadened HA recognition and increased antibody secreting cells to HA stem following H1N1 challenge

Abstract: How infection shapes recall responses in the setting of preexisting influenza virus hemagglutinin (HA) stem-focused immunity has important implications given the known…

Date: 2026-08-31