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Extreme phenotype-derived machine learning reveals susceptibility and resilience signatures for severe diabetic retinopathy

Abstract: The mechanisms underlying why some individuals with diabetes develop severe diabetic retinopathy (DR), whereas others remain free of retinal complications despite…

Date: 2026-08-27

Distinct metabolic phenotypes in adolescents with obesity identified by unsupervised learning: associations with insulin resistance and resting energy expenditure

Abstract: Pediatric obesity is characterized by substantial metabolic heterogeneity, including adiposity, insulin resistance, inflammation, and energy metabolism. Traditional…

Date: 2026-08-27

Joint trajectories of adiposity and systemic inflammation and incident diabetes among older adults: a bi-cohort prospective study with mediation analysis

Abstract: Obesity and chronic low-grade inflammation are established risk factors for type 2 diabetes, yet their joint longitudinal evolution and combined contribution to diabetes…

Date: 2026-08-27

Low baseline HbA1c and reduced eGFR are associated with relatively unfavorable body recomposition after SGLT2 inhibitor therapy in type 2 diabetes

Abstract: Sodium-glucose cotransporter 2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP-1RAs) improve glycemic control and promote weight loss, but their…

Date: 2026-08-27

Effectiveness and renal safety of dupilumab in the treatment of moderate-to-severe atopic dermatitis patients with chronic kidney disease stages 4–5: a real-world cohort study in China

Abstract: While dupilumab is widely used for atopic dermatitis (AD), its safety and effectiveness in patients with severe renal failure remain insufficiently studied. To evaluate…

Date: 2026-08-27

CFTR mutations and genotypic patterns among cystic fibrosis patients with allergic bronchopulmonary aspergillosis: analysis from a tertiary care center in Saudi Arabia

Abstract: Cystic fibrosis (CF) is a multisystem disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Allergic bronchopulmonary…

Date: 2026-08-27

Longitudinal developmental trajectories of weight-standardized lung function in preterm (28–36?+?6 weeks) vs. term infants and independent perinatal risk factors: a single-center prospective cohort study

Abstract: To compare weight-normalized tidal lung function trajectories from corrected 40 weeks to 6 months postmenstrual age (PMA) between preterm infants (28–36?+?6 weeks…

Date: 2026-08-27

Development and validation of a predictive model for myocardial injury in children with pneumonia based on interpretable machine learning

Abstract: This study aimed to identify independent factors for pneumonia-related myocardial injury in children, and construct and validate a risk prediction model and…

Date: 2026-08-27

Application of multidisciplinary collaborative nursing intervention based on King’s Goal Attainment Theory in medical transition readiness of adolescents with chronic kidney disease

Abstract: To explore the application effect of multidisciplinary collaborative nursing intervention based on King's Goal Attainment Theory on medical transition readiness in…

Date: 2026-08-27

Phosphoproteomic analysis in a mouse model reveals ERK signaling as a key modulator of inflammatory response in nasal mucosa associated with childhood allergic rhinitis

Abstract: Childhood allergic rhinitis (AR) is a multifactorial condition arising from the interplay between genetic predisposition and environmental exposures. Although protein…

Date: 2026-08-27