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Efficacy and safety of bevacizumab plus XELOX in patients with unresectable locally advanced or metastatic neuroendocrine tumors

Abstract: Neuroendocrine tumors (NETs) are highly vascularized malignancies for which effective treatment options remain limited in the unresectable locally advanced or metastatic…

Date: 2026-09-30

Preoperative biopsy underestimates tumour budding but retains prognostic value in oral squamous cell carcinoma

Abstract: Tumour budding is an established prognostic marker in oral squamous cell carcinoma (OSCC), but its reliability and prognostic performance in preoperative biopsy…

Date: 2026-09-30

Implementation and feasibility of DPYD-guided fluoropyrimidine use in a gastrointestinal oncology clinic at an academic medical center

Abstract: Genetic variation in DPYD can result in reduced fluoropyrimidine (FP) metabolism and increased risk of severe toxicity. This DPYD test implementation pilot aimed to…

Date: 2026-09-30

Beyond detection: developing probabilistic hemodynamic phenotyping after a positive point-of-care pulmonary hypertension test

Abstract: Pulmonary hypertension (PH) is a heterogeneous condition in which hemodynamic subtype directs management and specialist referral. PH can be identified non-invasively at…

Date: 2026-09-30

Association between patent foramen ovale and anxiety: a prospective study with deep learning-assisted analysis of contrast echocardiography

Abstract: To prospectively investigate the association between patent foramen ovale (PFO), detected via agitated saline contrast echocardiography (ASCE), and anxiety using a deep…

Date: 2026-09-30

Association between lesion-specific fat attenuation index and high-risk plaque on coronary computed tomography angiography

Abstract: To investigate the association between lesion-specific fat attenuation index (FAI) derived from coronary computed tomography angiography (CCTA) and CCTA-defined…

Date: 2026-09-30

Effect of rosuvastatin and ezetimibe therapy on LDL-cholesterol reduction and non-invasive arterial injury markers in children with heterozygous familial hypercholesterolemia: a prospective, open-label, randomized study

Abstract: Individuals with familial hypercholesterolemia (FH) require early lipid-lowering therapy (LLT). We compared rosuvastatin versus ezetimibe treatment and the role of major…

Date: 2026-09-29

Early prediction of 3-month functional outcome after acute ischemic stroke: an explainable model based on routine clinical data

Abstract: Accurate early prediction of 3-month functional outcome after acute ischemic stroke is essential for prognostic communication, early management planning, and resource…

Date: 2026-09-29

Comparative accuracy of automated carbohydrate estimation using NutriDish and ChatGPT-5 against dietitian-derived reference values

Abstract: Accurate carbohydrate estimation is critical for insulin dosing in individuals with diabetes on multiple daily injections. Conventional methods such as visual estimation…

Date: 2026-09-29

Identifying a high-risk CKM syndrome phenotype: association of albuminuria with subclinical hemodynamic alterations via portable noninvasive cardiometer

Abstract: Type 2 diabetes mellitus (T2DM) is closely linked to heart failure. This prospective study of 274 asymptomatic patients with T2DM without clinical heart failure or…

Date: 2026-09-29