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Prognostic nutritional index in evaluating the prognosis of ICIs in patients with advanced esophageal squamous carcinoma

Abstract: This study aimed to investigate the association between the Prognostic Nutritional Index (PNI) and the prognosis of advanced esophageal squamous cell carcinoma (ESCC)…

Date: 2026-08-24

HAIC combined with atezolizumab and bevacizumab versus lenvatinib in advanced hepatocellular carcinoma: a multicenter propensity score matching analysis

Abstract: This study aimed to evaluate the clinical efficacy and safety of hepatic arterial infusion chemotherapy (HAIC) combined with atezolizumab and bevacizumab (HTA) versus…

Date: 2026-08-24

Inflammation and iron metabolism dysregulation as hallmarks of COVID-19 severity

Abstract: Coronavirus Disease 2019 (COVID-19) can cause severe clinical outcomes by triggering an excessive immune response and systemic inflammation. As disease severity…

Date: 2026-08-24

Impact of drug coated balloon on left anterior descending artery stenosis at proximal to myocardial bridge

Abstract: Drug-coated balloons (DCB) represent a novel therapeutic approach for treating native coronary artery disease. However, the clinical outcomes of DCB in patients with…

Date: 2026-08-24

H4K5 lactylation exacerbates acute myocarditis by driving a positive feedback loop between inflammation and metabolic dysfunction

Abstract: Acute myocarditis is a non-ischemic cardiomyopathy with rapid onset and high mortality. Immunometabolic reprogramming of macrophages is a key pathological feature.…

Date: 2026-08-24

Association of social restrictions with fear of cancer recurrence in hematopoietic stem cell transplantation patients: an exploratory analysis of the potential chain mediation role of illness perception and cognitive emotion regulation

Abstract: To explore the potential association between social restrictions and FCR in patients who underwent HSCT, and preliminarily investigate whether examine whether illness…

Date: 2026-08-21

Graded and threshold effects of body mass index on perioperative outcomes after pancreaticoduodenectomy: a meta-analysis incorporating an institutional cohort

Abstract: The influence of body mass index (BMI) on perioperative results after pancreaticoduodenectomy (PD) remains controversial. This study aimed to clarify how different BMI…

Date: 2026-08-21

A primary hepatopancreatic cell platform enables cellular dissection of glucose metabolism and endocrine-metabolic regulation in Litopenaeus vannamei

Abstract: The lack of robust continuous cell lines remains a major bottleneck limiting cell-level mechanistic dissection of endocrine and metabolic regulation in crustaceans. In…

Date: 2026-08-21

iGlarlixi for the simplification of more complex insulin regimens in type 2 diabetes patients with good glycaemic control

Abstract: Knowledge on insulin treatment simplification with fixed ratio combinations (e.g. iGlarLixi, combination of insulin glargine and lixisenatide) is limited. Our aim was to…

Date: 2026-08-21

Visual and lesion descriptor fusion using cross-attention for skin disease diagnosis

Abstract: Accurate and early diagnosis of skin disease remains a significant challenge in clinical dermatology due to variation in skin tones and visual similarity among disease…

Date: 2026-08-21