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Predicting post-ESD bleeding in elderly patients with early gastrointestinal cancer: an explainable model based on endoscopic features

Abstract: Endoscopic submucosal dissection (ESD) has emerged as the treatment of choice for early gastrointestinal cancers due to its minimally invasive nature, short recovery…

Date: 2026-08-12

Real-world pharmacovigilance assessment of meropenem-associated adverse events: age stratification and time-to-onset analysis using FAERS

Abstract: Meropenem is a broad-spectrum carbapenem antibiotic widely used for severe infections; however, its real-world adverse event profile and age-stratified pharmacovigilance…

Date: 2026-08-12

Relationship between insomnia and cognitive function in elderly Chinese cerebral small vessel disease patients: mediating effect of neutrophil-to-lymphocyte ratio

Abstract: This exploratory study investigated the relationship between insomnia, neutrophil-to-lymphocyte ratio (NLR), and cognitive function in elderly Chinese cerebral small…

Date: 2026-08-12

? -Hydroxybutyrate induces microglial M2 polarization by inhibiting the NF-?B/NLRP3 pathway to ameliorate cerebral ischemia–reperfusion injury

Abstract: To investigate the neuroprotective effects of ? -hydroxybutyrate (BHB) on cerebral ischemia–reperfusion injury (CIRI) and its underlying molecular mechanisms; to clarify…

Date: 2026-08-12

Integrative multi-omics and machine learning analysis identifies candidate biomarkers associated with mitochondrial quality control in major depressive disorder

Abstract: Major depressive disorder (MDD) possesses a complex pathogenesis, with abnormal mitochondrial quality control (MQC) proposed as a potential mechanism involved in the…

Date: 2026-08-12

Hypoperfused tissue salvage after selective intra-arterial hypothermia during mechanical thrombectomy for anterior circulation large-vessel occlusion

Abstract: To evaluate whether selective intra-arterial hypothermia during mechanical thrombectomy is associated with greater preservation of initially hypoperfused tissue in…

Date: 2026-08-12

The impact of OSCAR-IB quality control and manual segmentation on retinal atrophy rates in multiple sclerosis

Abstract: Inner retinal layer thinning, particularly of the peripapillary retinal nerve fiber layer (pRNFL) and the ganglion cell-inner plexiform layer (GCIPL), as measured by…

Date: 2026-08-12

Plasma metabolomic signatures of air pollution and rheumatoid arthritis risk

Abstract: Ambient air pollutants have been increasingly implicated in immune-mediated disorders, yet the metabolic perturbations through which long-term exposure may contribute to…

Date: 2026-08-12

Allocative inefficiency in physician workforce distribution: specialty-level NHI-covered reimbursement analysis in South Korea’s single-payer system

Abstract: About 52 million residents are insured under the single-payer National Health Insurance (NHI) of South Korea. Twenty-six board-certified clinical specialties practice…

Date: 2026-08-12

BCG overexpressing Ag85B reprograms host immune response through coordinated transcriptional networks

Abstract: Antigen 85B (Ag85B), an immunodominant protein secreted by Mycobacterium tuberculosis (Mtb), induces robust T-cell-mediated immunity in host cells. Previous studies have…

Date: 2026-08-12