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Lacunar stroke with and without chronic imaging biomarkers of small vessel disease: clinical profiles and stroke etiology

Abstract: Chronic cerebral small vessel disease (CSVD) may help distinguish different etiological mechanisms in acute lacunar stroke; this study aimed to compare vascular risk…

Date: 2026-08-05

Interferon-?-induced tolerogenic dendritic cells ameliorate autoimmune neuroinflammation and suppress T-cell responses in multiple sclerosis

Abstract: Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system characterized by immune-mediated demyelination and neuroinflammation resulting from…

Date: 2026-08-05

Serum metabolomics modelling reveals stage-associated purine and endocannabinoid metabolic signatures in colorectal cancer progression

Abstract: Colorectal cancer (CRC) remains one of the major challenges in contemporary oncology. Despite advances in imaging diagnostics and histopathological assessment, we still…

Date: 2026-08-05

Dual optimization in single-isocenter radiosurgery for multiple brain metastases: a dosimetric planning study

Abstract: This study evaluated a dual-optimization strategy for single-isocenter multiple-target stereotactic radiosurgery (SIMT-SRS) in patients with multiple brain metastases,…

Date: 2026-08-05

The role of the preoperative HALP score in predicting pathological T and N categories in colon cancer: a single-center retrospective study

Abstract: The HALP score is an easily accessible immunonutritional biomarker that may reflect systemic inflammation and nutritional status. This study aimed to evaluate the…

Date: 2026-08-05

The combined compartmental maxillary resection: technique codification and preliminary multicenter series analysis

Abstract: Maxillary cancers extending to the deep craniofacial spaces represent one of the most challenging scenarios in head and neck oncology. Integrating compartmental surgery…

Date: 2026-08-05

Perioperative outcomes and prognostic determinants in adult spindle cell/sclerosing rhabdomyosarcoma: implications of treatment intensity, surgical margins, and molecular heterogeneity

Abstract: Spindle cell/sclerosing rhabdomyosarcoma (ssRMS) represents an uncommon and biologically heterogeneous soft tissue sarcoma with clinical outcomes in adults markedly…

Date: 2026-08-05

192 Ir brachytherapy combined with external beam radiotherapy and biliary stenting for unresectable hilar cholangiocarcinoma

Abstract: To evaluate the efficacy and safety of 192 Ir brachytherapy combined with external beam radiotherapy (EBRT) and biliary stenting in patients with unresectable hilar…

Date: 2026-08-05

Downstaging therapy of intermediate-stage hepatocellular carcinoma: microwave ablation vs. surgical resection

Abstract: Transarterial chemoembolization(TACE) is a potential downstaging therapeutic strategy for intermediate-stage hepatocellular carcinoma(HCC). However, therapeutic options…

Date: 2026-08-05

Assessing real-world evidence utilization in oncology health technology assessments: insights from external control-arm studies

Abstract: While health technology assessment (HTA) acceptance of contextual real-world data (RWD) studies describing burden of disease, disease natural history, or treatment…

Date: 2026-08-05