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Clinical outcomes of intrathecal anti-PD-1 therapy with or without whole-brain radiotherapy in melanoma leptomeningeal metastasis: a multicenter retrospective study

Abstract: Leptomeningeal metastases (LM) from melanoma are rare and associated with dismal outcomes. Intrathecal PD-1 antibody therapy has shown encouraging activity in LM.…

Date: 2026-07-27

Risk factors for severe radiation-induced dermatitis in nasopharyngeal carcinoma patients undergoing radiotherapy

Abstract: Radiation-induced dermatitis (RID) is a common toxicity in patients with nasopharyngeal carcinoma (NPC) undergoing radiotherapy. This study aimed to evaluate the…

Date: 2026-07-27

Clinically detected hepatitis B virus reactivation in HBsAg-negative, anti-HBc-positive breast cancer patients receiving systemic therapy without antiviral prophylaxis: a two-centre descriptive cohort and nested case study

Abstract: Hepatitis B virus (HBV) reactivation is a recognised complication in HBsAg-negative, anti-HBc-positive patients receiving cytotoxic cancer therapy. Guidelines place…

Date: 2026-07-27

Prospective evaluation of dynamic changes in L3 skeletal muscle index and chemotherapy-induced peripheral neuropathy during albumin-bound paclitaxel chemotherapy

Abstract: This prospective study aimed to assess the association between dynamic changes in the L3 skeletal muscle index (L3SMI) and chemotherapy-induced peripheral neuropathy…

Date: 2026-07-27

Identifying and profiling authoritative cardiology-related key opinion leaders on Xiaohongshu: a social media-based study

Abstract: To identify and characterize distinct types of authoritative cardiology-related key opinion leaders (ACKOLs) on Xiaohongshu and examine their communication…

Date: 2026-07-27

Insulin sensitivity and cardiovascular risk after revascularization: associations with remodeling and long-term outcomes

Abstract: Insulin resistance may influence myocardial recovery after ischemic injury, but its relevance to post-revascularization remodeling and long-term outcomes remains…

Date: 2026-07-27

Association between nocturnal blood pressure dipping patterns and left atrial reservoir strain in untreated adults with office-defined grade 1 essential hypertension

Abstract: Abnormal nocturnal blood pressure (BP) profiles may expose the left atrium to persistent hemodynamic load before overt remodeling occurs. This study evaluated the…

Date: 2026-07-27

Down-regulation of THBS2 inhibits the malignant progression of Burkitt lymphoma by blocking the PI3K/AKT/c-MYC pathway

Abstract: Thrombospondin 2 (THBS2) is overexpressed in various solid tumors and is a prognostic gene of Burkitt lymphoma (BL), but its role and molecular mechanism in BL still…

Date: 2026-07-24

Adequacy of electronic and in-person referrals to endocrinology: a prospective study of primary care and hospital consultations

Abstract: To assess the adequacy of electronic consultations (e-consults) and in-person referrals to an endocrinology department, to describe patterns and causes of inadequacy,…

Date: 2026-07-24

The association between SGLT2 inhibitor use and diabetic peripheral neuropathy in type 2 diabetes: a cross-sectional study

Abstract: This study assessed the association between sodium-glucose cotransporter 2 (SGLT2) inhibitor use and the prevalence of diabetic peripheral neuropathy (DPN) in patients…

Date: 2026-07-24