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Somatotropic axis drives bone turnover heterogeneity independently of gonadotropin synergy in girls with central precocious puberty

Abstract: The classic paradigm of somatotropic-gonadal axis synergy in pubertal bone acquisition lacks validation in central precocious puberty (CPP), and the driver of the…

Date: 2026-07-22

Association of primary-site surgery with survival in patients with metastatic gastroenteropancreatic neuroendocrine carcinoma: a population-based SEER study (2004–2023)

Abstract: Evidence regarding the association between primary tumor surgery and survival in metastatic gastroenteropancreatic neuroendocrine carcinoma (GEP-NEC) remains limited,…

Date: 2026-07-22

Systemic inflammatory biomarkers (NLR, SII, PNI and FPR) combined with CEA for predicting advanced colorectal neoplasms: development and temporal validation of a machine learning model

Abstract: Chronic systemic inflammation is closely associated with the initiation and development of colorectal tumors. Biomarkers reflecting inflammatory status may help detect…

Date: 2026-07-22

Evaluating the internal structure validity of admissions measures: do they capture distinct attributes?

Abstract: Veterinary admissions committees aim to select applicants who will successfully complete a Doctor of Veterinary Medicine (DVM) program and contribute effectively to the…

Date: 2026-07-22

Optimizing cardiovascular disease diagnosis through machine learning models integrating oxidized low-density lipoprotein and routine clinical indicators

Abstract: To evaluate the diagnostic value of oxidized low-density lipoprotein cholesterol (oxLDL-C) for cardiovascular disease (CVD) and to construct a machine learning model…

Date: 2026-07-22

HDL-C presents a suggestive negative moderating trend for the association between total cholesterol and colorectal polyps: model construction and bootstrap internal assessment of a predictive nomogram

Abstract: Colorectal polyps are classic precancerous lesions of colorectal cancer, closely linked to lipid metabolic disorders. Elevated total cholesterol does not consistently…

Date: 2026-07-22

Designing an integrated data model for prospective genotype-phenotype in inborn errors of immunity research

Abstract: Inborn errors of immunity are rare, genetically heterogeneous disorders requiring coordinated clinical, laboratory, and genetic evaluation over time. Data are often…

Date: 2026-07-22

Prognostic value and clinical net benefit of global longitudinal strain in sepsis: a prospective study with internal bootstrap validation

Abstract: Conventional left ventricular ejection fraction (LVEF) often fails to detect early sepsis-induced myocardial dysfunction (SIMD). This study aimed to evaluate the…

Date: 2026-07-22

Using interpretable machine learning model to predict lymph node metastasis in patients with localized prostate cancer

Abstract: This study aimed to develop and externally validate machine learning (ML) models for predicting lymph node metastasis (LNM) in patients with localized prostate cancer…

Date: 2026-07-22

Interpretable bioimpedance-based modeling of body composition and metabolic indices related to physical function in maintenance hemodialysis patients

Abstract: In maintenance hemodialysis (MHD) patients, muscle wasting and altered body composition are major determinants of reduced physical function. This study aimed to identify…

Date: 2026-07-22