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Dual inhibition of CSF-1R and IDO modulates the fibrotic and immunosuppressive tumor microenvironment in pancreatic ductal adenocarcinoma

Abstract: Pancreatic ductal adenocarcinoma (PDAC), one of the most aggressive forms of solid tumors, is characterized by extensive fibrosis and an immunosuppressive tumor…

Date: 2026-07-15

Association of the C-reactive protein-triglyceride glucose index with microvascular obstruction and long-term prognosis in patients with acute myocardial infarction: a CMR-based study

Abstract: The clinical benefits of percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI) are frequently compromised by the occurrence of microvascular…

Date: 2026-07-15

Risk stratification and real-world management of pediatric AAORCA: discordance between anatomical features and clinical symptoms

Abstract: Anomalous aortic origin of the right coronary artery (AAORCA) is increasingly identified in children, yet risk stratification remains controversial. This study aims to…

Date: 2026-07-15

Rivaroxaban plus antiplatelet therapy for coronary artery ectasia: 36-month outcomes and risk prediction from a retrospective cohort study

Abstract: Coronary artery ectasia (CAE) is characterized by abnormal coronary dilation and slow flow, predisposing patients to thrombotic complications. Optimal long-term…

Date: 2026-07-15

Temporal trends in clinical and inflammatory features of Kawasaki disease across the COVID-19 pandemic: a single-center experience from Turkey

Abstract: The COVID-19 pandemic has been associated with changes in the epidemiology and clinical presentation of pediatric inflammatory diseases, including Kawasaki disease (KD).…

Date: 2026-07-15

Development and validation of a deep neural network for predicting coronary heart disease in hypertensive patients using 24-hour ambulatory blood pressure monitoring: a retrospective study

Abstract: Coronary heart disease (CHD) remains a leading cause of morbidity and mortality worldwide. Early identification of high-risk hypertensive patients is crucial for…

Date: 2026-07-15

Quantifying red blood cell compatibility beyond ABO and RhD: a recipient-centered model for matching, allocation, and inventory curation

Abstract: Recipient alloimmunization remains the most frequent adverse effect of transfusion therapy. Routine transfusion decisions rely heavily on clinician judgment and informal…

Date: 2026-07-14

Pharmacokinetic-guided versus weight-guided coagulation factor replacement in hemophilia patients undergoing arthroplasty: a retrospective real-world study on perioperative bleeding risk and economic outcomes

Abstract: This study aimed to compare the perioperative bleeding risk and economic outcomes of pharmacokinetic (PK)-guided versus weight-guided coagulation factor replacement…

Date: 2026-07-14

Immediate versus delayed short-course ruxolitinib for acute GVHD prophylaxis after myeloablative allogeneic hematopoietic stem cell transplantation

Abstract: The optimal timing of ruxolitinib initiation for acute graft-versus-host disease (aGVHD) prophylaxis after myeloablative allogeneic hematopoietic stem cell…

Date: 2026-07-14

Tuber intake is independently associated with reduced risk of Hashimoto’s thyroiditis: a community-based cross-sectional study

Abstract: Hashimoto’s thyroiditis (HT) is the leading cause of autoimmune hypothyroidism, and dietary factors have been implicated in its pathogenesis through immune and metabolic…

Date: 2026-07-14