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Berberine alleviates biofilm-associated immune-inflammatory injury in Staphylococcus aureus -induced osteomyelitis: insights from network pharmacology and experimental validation

Abstract: Staphylococcus aureus (SA)-induced osteomyelitis (OM) is a common orthopedic infection characterized by biofilm formation and persistent inflammation. Berberine (BBR), a…

Date: 2026-07-13

Construction and application of a smart hospital platform-based VTE risk management system

Abstract: Venous thromboembolism (VTE) ranks as the third most prevalent cardiovascular disease after acute myocardial infarction and stroke, posing a significant risk to patient…

Date: 2026-07-13

An integrated, wearable, tubeless micro-negative pressure system for closed incision management: a translational preclinical and clinical study

Abstract: Closed incision management remains a challenge in postoperative care, largely due to the difficulty of maintaining a stable wound microenvironment in routine clinical…

Date: 2026-07-13

Caffeine use disorder and analgesic dependence in medication-overuse headache: insights into an underrecognized relationship

Abstract: Caffeine plays a dual role in headache disorders, acting as an analgesic adjuvant while potentially contributing to headache chronification. Its relationship with…

Date: 2026-07-13

A novel H2A-A127 variant is associated with human cancer and enhances tumor-related phenotypes in Drosophila melanogaster models

Abstract: Acute Myeloid Leukemia (AML) is characterized by genetic and epigenetic dysregulation in myeloid progenitor cells. Histone H3 mutations disrupt chromatin and…

Date: 2026-07-13

WCRF/AICR dietary adherence-associated metabolic bridge phenotypes and incident lung cancer risk: a prospective cohort study of the UK Biobank

Abstract: Lung cancer is the leading cause of cancer-related mortality worldwide. Although the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR)…

Date: 2026-07-13

Disproportionality analysis of drug-related interstitial lung disease in patients with head and neck squamous cell carcinoma: a signal mining study

Abstract: With the widespread use of novel therapeutic agents, an increasing number of drugs have been confirmed to be associated with interstitial lung disease (ILD). However,…

Date: 2026-07-13

Neoadjuvant chemoimmunotherapy versus chemoradiotherapy for esophageal squamous cell carcinoma: a multicenter cohort study

Abstract: The comparative efficacy of neoadjuvant chemoimmunotherapy (NCIT) vs neoadjuvant chemoradiotherapy (NCRT) for locally advanced esophageal squamous cell carcinoma…

Date: 2026-07-13

Mechanistic insights into lipoprotein(a)-induced cardiomyocyte ferroptosis via ROS/p38/p53 signaling

Abstract: Lipoprotein(a) [Lp(a)], a low-density lipoprotein-like molecule covalently linked to apolipoprotein (a), is a residual cardiovascular risk factor with established…

Date: 2026-07-13

Cumulative triglyceride-glucose-body mass index exposure and cardiovascular disease risk: findings from the Kailuan study

Abstract: The relationship between cumulative triglyceride-glucose-body mass index (TyG-BMI) exposure and the risk of cardiovascular disease (CVD) has been unclear. This study…

Date: 2026-07-13