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Intraoperative irreversible electroporation for margin accentuation in locally advanced intrahepatic cholangiocarcinoma: a case series

Abstract: The incidence of intrahepatic cholangiocarcinoma (iCCA) is increasing worldwide and remains associated with a poor prognosis. Surgical resection is the only potentially…

Date: 2026-06-29

BIRC3-CASP8 axis orchestrates the PANoptosis spectrum: taming the inflammatory storm to prevent post-ischemic heart failure

Abstract: The progression of heart failure (HF) following myocardial ischemia/reperfusion (I/R) injury is driven by regulated cell death. Unlike the restrained nature of…

Date: 2026-06-29

Several antiplatelet gene SNPs, their haplotypes and G × E interactions on premature coronary artery disease

Abstract: To investigate the impact of single nucleotide polymorphisms (SNPs) and haplotypes of antiplatelet drug metabolism-related genes— CYP2C19 , PTGS1 , ITGB3 , PEAR1 , and…

Date: 2026-06-29

The value of speckle tracking echocardiography in early identification of subclinical cardiac involvement in patients with multiple myeloma: a pilot retrospective study

Abstract: Multiple myeloma (MM) is frequently associated with cardiac involvement, particularly myocardial amyloidosis. Current gold-standard diagnostic modalities include cardiac…

Date: 2026-06-26

miR-1248 enhances bortezomib-induced autophagy by targeting MEF2C/p38-MAPK signaling in multiple myeloma

Abstract: Multiple myeloma (MM) is incurable and many patients respond poorly to bortezomib. New strategies to improve bortezomib sensitivity are needed. We screened…

Date: 2026-06-26

Multicenter study on magnesium isoglycyrrhizinate preventing novel antitumor-induced liver injury in hematological malignancies

Abstract: Antineoplastic agents significantly contribute to drug-induced liver injury (DILI). This study evaluates magnesium isoglycyrrhizinate (MgIG) for preventing DILI in…

Date: 2026-06-26

Engineering with EP2/EP4 knockout and IL-15 transpresentation renders stem cell-derived NK cells self-persistent and resistant to PGE2 inhibition

Abstract: Adoptive Natural Killer (NK) cell transfer is a promising therapy for the treatment of cancer. We developed a GMP-compliant protocol to generate NK cells from…

Date: 2026-06-26

From islet to blood: macrophage remodeling signatures for diagnosis and risk stratification in type 1 diabetes

Abstract: Type 1 diabetes (T1D) is an autoimmune disease characterized by progressive ?-cell destruction, yet current risk stratification tools, which rely mainly on genetic…

Date: 2026-06-26

Association of antiretroviral therapy regimens with serum cortisol abnormalities in people living with HIV/AIDS: a retrospective study

Abstract: The life expectancy of people living with HIV (PLWH) has significantly increased, largely due to the antiretroviral therapy (ART) used very frequently. To explore the…

Date: 2026-06-26

Psychological distress, but not single-time endocrine stress markers, is associated with unexplained infertility: a prospective case–control study

Abstract: Psychological distress is common among women with unexplained infertility and may interact with neuroendocrine stress pathways. However, the relevance of single-time…

Date: 2026-06-26